{"id":"W2509320806","doi":"10.1016/j.virusres.2016.08.008","title":"Alfalfa dwarf cytorhabdovirus P protein is a local and systemic RNA silencing supressor which inhibits programmed RISC activity and prevents transitive amplification of RNA silencing","year":2016,"lang":"en","type":"article","venue":"Virus Research","topic":"Plant Virus Research Studies","field":"Agricultural and Biological Sciences","cited_by":20,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Agriculture and Agri-Food Canada; Australian Research Council; University of Queensland; Queensland University of Technology; Department of Agriculture, Fisheries and Forestry, Australian Government","keywords":"Biology; Gene silencing; RNA-induced silencing complex; Trans-acting siRNA; RNA silencing; Small interfering RNA; Argonaute; RNA-induced transcriptional silencing; RNA; RNA interference; Cell biology; RNA-binding protein; Molecular biology; Genetics; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002369984,0.0002569587,0.0004351823,0.0001153568,0.0005682075,0.0001128623,0.0003394982,0.0001997798,0.00005183637],"category_scores_gemma":[0.0007828039,0.000103067,0.00006212857,0.000844344,0.0006279906,0.0004326031,0.0003776655,0.0004280781,0.00002824412],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001638713,"about_ca_system_score_gemma":0.00007678352,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005143437,"about_ca_topic_score_gemma":0.002266202,"domain_scores_codex":[0.9956905,0.0009608838,0.0003861135,0.0007822482,0.001274128,0.0009061037],"domain_scores_gemma":[0.9975934,0.001257391,0.0001453333,0.0001519076,0.0005552212,0.0002967236],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000382572,0.0001141391,0.0003327009,0.0001750349,0.00004764568,0.000005637437,0.0007079779,2.497426e-7,0.8366602,0.00001383352,0.00008207551,0.1614779],"study_design_scores_gemma":[0.0004652322,0.0005982674,0.0155486,0.0008178593,0.00001043213,0.00001047205,0.0009283944,0.000156214,0.9809937,0.0001450757,0.0001090866,0.0002166431],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952489,0.0008422513,0.0001248571,0.0009190702,0.00001607926,0.001985862,0.0006965421,0.00004838042,0.0001181199],"genre_scores_gemma":[0.9980601,0.001232265,0.00004470208,0.000009373555,0.00007403992,0.0003743076,0.00000764229,0.000004656294,0.0001929097],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1612613,"threshold_uncertainty_score":0.7775372,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06888453415817956,"score_gpt":0.3156563219484974,"score_spread":0.2467717877903178,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}