{"id":"W2509369257","doi":"10.1371/journal.pone.0161587","title":"The O-Antigen Flippase Wzk Can Substitute for MurJ in Peptidoglycan Synthesis in Helicobacter pylori and Escherichia coli","year":2016,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Bacterial Genetics and Biotechnology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada; National Institutes of Health","keywords":"Flippase; Lipid II; Peptidoglycan; Biology; Cell envelope; Bacillus subtilis; Escherichia coli; Biogenesis; Biochemistry; ATP-binding cassette transporter; Lipid bilayer; Inner membrane; Bacterial outer membrane; Cell biology; Microbiology; Cell wall; Bacteria; Transporter; Phosphatidylserine; Genetics; Phospholipid","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001303225,0.0002796332,0.0002717911,0.0002008333,0.0001053961,0.0003724347,0.0002178855,0.0003144176,0.0003049178],"category_scores_gemma":[0.0002833072,0.0002163195,0.0002086663,0.0002071854,0.0002957512,0.0002526488,0.0004977916,0.0003345626,0.0003001836],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000376689,"about_ca_system_score_gemma":0.0002497997,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001117646,"about_ca_topic_score_gemma":0.0009215921,"domain_scores_codex":[0.9998511,0.00002734337,0.00002172843,0.00001915042,0.00004331673,0.00003735863],"domain_scores_gemma":[0.9998527,0.00002717097,0.00004975521,0.00002346957,0.00001296207,0.00003402924],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001660678,0.00003229975,0.0006434927,0.00002885933,0.000004296398,0.0001636485,0.0000163012,0.0001461213,0.997538,0.0002594062,0.00001527345,0.0009861809],"study_design_scores_gemma":[0.00004064084,0.000325805,0.01010957,0.00001301774,0.00003294109,0.0006896924,0.000152863,0.003831773,0.9828929,0.0002075965,0.001689157,0.00001399946],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984621,0.0002204561,0.0007710506,0.00005192653,0.000007368683,0.000007509748,0.00004951539,0.00001306562,0.0004171008],"genre_scores_gemma":[0.9979232,0.0001381132,0.001135822,0.00002564805,0.000002083028,0.000009072542,0.0001456284,0.00001460468,0.0006057285],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001117646,"threshold_uncertainty_score":0.002733052,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01927323290063333,"score_gpt":0.2096986096396253,"score_spread":0.190425376738992,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}