{"id":"W2509545693","doi":"10.1038/srep31817","title":"Staphylokinase has distinct modes of interaction with antimicrobial peptides, modulating its plasminogen-activation properties","year":2016,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Canadian Institutes of Health Research","keywords":"Staphylokinase; Melittin; Antimicrobial peptides; Plasminogen activator; Docking (animal); Chemistry; Antimicrobial; Activator (genetics); Biochemistry; Biology; Recombinant DNA; Microbiology; Peptide; Genetics; Receptor; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001250049,0.0002872402,0.0002395932,0.00008680853,0.00009321835,0.0003192769,0.0001569723,0.0002494134,0.0006999556],"category_scores_gemma":[0.0001733206,0.00008558317,0.0002457221,0.0001348698,0.0002201697,0.0001997074,0.0002012483,0.0003179838,0.0002125711],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002000869,"about_ca_system_score_gemma":0.0001034921,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003029081,"about_ca_topic_score_gemma":0.0002959867,"domain_scores_codex":[0.9998302,0.00004038758,0.00001292038,0.00003094796,0.0000416509,0.00004390519],"domain_scores_gemma":[0.9999053,0.00001810941,0.00002704169,0.000007545438,0.00001059498,0.00003135515],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001626931,0.00001543616,0.0006475627,0.00004172073,0.000006204315,0.00007094797,0.00001439721,0.00006255251,0.9971938,0.00006827133,0.00001414764,0.00170215],"study_design_scores_gemma":[0.00001975589,0.0004910762,0.009246679,0.000006839085,0.00001706605,0.0009312632,0.00006224164,0.001116885,0.9863338,0.00008681019,0.001676754,0.00001092619],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948303,0.001697489,0.00211876,0.00005547317,0.00001116633,0.000009669495,0.00005331878,0.00001387758,0.001210027],"genre_scores_gemma":[0.9969085,0.000422946,0.001592984,0.0000318625,0.000004525959,0.000007167082,0.00007901942,0.000004035593,0.000949099],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006999556,"threshold_uncertainty_score":0.002341628,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03033036750289931,"score_gpt":0.221848277069028,"score_spread":0.1915179095661287,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}