{"id":"W2509787928","doi":"10.1212/nxi.0000000000000277","title":"Restoring immune tolerance in neuromyelitis optica","year":2016,"lang":"en","type":"review","venue":"Neurology Neuroimmunology & Neuroinflammation","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":57,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Neurological Institute and Hospital","funders":"Guthy-Jackson Charitable Foundation","keywords":"Neuromyelitis optica; Neuroscience; Immune system; Immunology; Medicine; Disease; Immune tolerance; Aquaporin 4; Bioinformatics; Biology; Multiple sclerosis; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":["metaepi_narrow","research_integrity"],"category_scores_codex":[0.0008982279,0.001844357,0.00447971,0.002120957,0.000507576,0.00007906236,0.002094835,0.002661861,0.0006743382],"category_scores_gemma":[0.001157853,0.001571197,0.001180468,0.001070342,0.001189017,0.0005729148,0.0006906952,0.004347641,0.004805478],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001662178,"about_ca_system_score_gemma":0.0005414066,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005142769,"about_ca_topic_score_gemma":0.00001088008,"domain_scores_codex":[0.9859184,0.006124311,0.003404248,0.002264338,0.0001771988,0.002111525],"domain_scores_gemma":[0.9919595,0.003313466,0.001755812,0.00277665,0.000137948,0.00005663569],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001176491,0.0002293382,0.00003019072,0.001356953,0.0003188351,0.0009496096,0.0001280026,0.00001108788,0.04046592,0.001089154,0.0002383602,0.9540061],"study_design_scores_gemma":[0.002451649,0.001048141,0.00235728,0.002948543,0.0002156353,0.004576873,0.000003922411,0.000002566442,0.000573757,0.0001089138,0.9846129,0.001099823],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01083972,0.9769846,0.00001788224,0.0008444163,0.007690737,0.002042301,0.0000690099,0.0005737172,0.0009375917],"genre_scores_gemma":[0.00155641,0.9942233,0.00001185766,0.0002706173,0.000198391,0.0005686286,0.0002372182,0.000380878,0.00255272],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9843745,"threshold_uncertainty_score":0.9994301,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02412678671364781,"score_gpt":0.2779262644302928,"score_spread":0.253799477716645,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}