{"id":"W2509787928","doi":"10.1212/nxi.0000000000000277","title":"Restoring immune tolerance in neuromyelitis optica","year":2016,"lang":"en","type":"review","venue":"Neurology Neuroimmunology & Neuroinflammation","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":57,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Neurological Institute and Hospital","funders":"Guthy-Jackson Charitable Foundation","keywords":"Neuromyelitis optica; Neuroscience; Immune system; Immunology; Medicine; Disease; Immune tolerance; Aquaporin 4; Bioinformatics; Biology; Multiple sclerosis; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003460041,0.0007070414,0.0007576398,0.001831867,0.0002589056,0.0006618557,0.0004691265,0.0009475459,0.001504178],"category_scores_gemma":[0.0003156872,0.0001616256,0.0002754519,0.001273832,0.0003985879,0.001011202,0.0006201613,0.001267224,0.001413233],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004034995,"about_ca_system_score_gemma":0.0005929876,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005621379,"about_ca_topic_score_gemma":0.001008613,"domain_scores_codex":[0.9998975,0.00001648076,0.00001744704,0.00001765812,0.00003841819,0.00001252811],"domain_scores_gemma":[0.9999127,0.00003109501,0.00001856479,0.000003303453,0.00002108372,0.00001319451],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00005839951,0.0000764373,0.0001448586,0.007356868,0.00002972867,0.0002291974,0.0000581917,0.0002376236,0.002858779,0.003142788,0.01823036,0.9675767],"study_design_scores_gemma":[0.00001438757,0.0001384796,0.000982558,0.001920893,0.00004567592,0.002677772,0.00007199865,0.00008946884,0.000967969,0.002071732,0.9910028,0.00001627591],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001869611,0.9983576,0.0001218914,0.0002128682,0.0002380666,0.000003828197,0.000006740291,0.000006000991,0.0008660373],"genre_scores_gemma":[0.001171386,0.9972338,0.0002031518,0.0001808925,0.0002450789,0.000006825307,0.00001697296,0.000001611077,0.0009404132],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001831867,"threshold_uncertainty_score":0.005032003,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02412678671364781,"score_gpt":0.2779262644302928,"score_spread":0.253799477716645,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}