{"id":"W2509844702","doi":"10.1158/1078-0432.ccr-16-1278","title":"High-Risk Premenopausal Luminal A Breast Cancer Patients Derive no Benefit from Adjuvant Cyclophosphamide-based Chemotherapy: Results from the DBCG77B Clinical Trial","year":2016,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Breast Cancer Treatment Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":57,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre for Advancing Health Outcomes","funders":"Forskerakademiet; Canadian Cancer Society","keywords":"Medicine; Internal medicine; Breast cancer; Oncology; Cyclophosphamide; Chemotherapy; Hazard ratio; Proportional hazards model; Tissue microarray; Cancer; Clinical endpoint; Randomized controlled trial; Confidence interval","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00165563,0.000664611,0.001575246,0.0001954191,0.0002765378,0.001134339,0.0005131483,0.001088599,0.003240929],"category_scores_gemma":[0.002239047,0.0002157,0.00147318,0.0003170424,0.0006649804,0.000467451,0.000269881,0.001438875,0.0005633612],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000749108,"about_ca_system_score_gemma":0.001110061,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001236058,"about_ca_topic_score_gemma":0.002705668,"domain_scores_codex":[0.999057,0.0005937114,0.00005446441,0.000110921,0.00008746782,0.0000965409],"domain_scores_gemma":[0.9988731,0.0003912517,0.0002382063,0.0001331401,0.00007063695,0.000293752],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.9544266,0.002743288,0.004509739,0.0008055339,0.00316414,0.00006708981,0.00004831436,0.000448527,0.002273822,0.0002699512,0.00241108,0.02883191],"study_design_scores_gemma":[0.8942367,0.06599253,0.02461288,0.0003266232,0.007212061,0.0001885504,0.0001063357,0.0007941685,0.00106308,0.0008697498,0.004551708,0.00004556933],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.979223,0.01350831,0.0001898888,0.001299432,0.0003376233,0.0003787836,0.001096205,0.00002925102,0.003937672],"genre_scores_gemma":[0.9917873,0.00311063,0.0002858522,0.001405952,0.0003192875,0.0002833985,0.001448332,0.00001223525,0.001347047],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003240929,"threshold_uncertainty_score":0.01084203,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07161111733640327,"score_gpt":0.4182395047963901,"score_spread":0.3466283874599868,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}