{"id":"W2510025743","doi":"10.1074/jbc.m116.741314","title":"Strong Enrichment of Aromatic Residues in Binding Sites from a Charge-neutralized Hyperthermostable Sso7d Scaffold Library","year":2016,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research","funders":"National Institute of General Medical Sciences; National Science Foundation; National Institutes of Health; National Cancer Institute; Austrian Science Fund; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology","keywords":"Sulfolobus solfataricus; Scaffold protein; Chemistry; Biophysics; Plasma protein binding; Bovine serum albumin; Biochemistry; Human serum albumin; Epitope; Binding site; Biology; Antibody; Signal transduction; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001097632,0.0004258042,0.0002870489,0.0002640016,0.0001516658,0.0002064693,0.0001746222,0.0002111209,0.001118853],"category_scores_gemma":[0.0001557631,0.00009790745,0.0002367795,0.0003616782,0.0001635533,0.000107294,0.0002780018,0.0003417777,0.0005162718],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000199137,"about_ca_system_score_gemma":0.0001466367,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003998423,"about_ca_topic_score_gemma":0.0006564873,"domain_scores_codex":[0.9998564,0.00001856539,0.00001134157,0.00002749602,0.00005517756,0.00003107096],"domain_scores_gemma":[0.9999069,0.00001425317,0.00002149076,0.00001071658,0.00002012398,0.00002649848],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003984264,0.00001184009,0.0001084236,0.00001560806,0.000004370376,0.00002921418,0.000008833523,0.00006818513,0.9986225,0.00002535733,0.00002308025,0.00104267],"study_design_scores_gemma":[0.000006750291,0.0001676122,0.001923266,0.000003398882,0.00001595176,0.0001587596,0.00002235629,0.0005520357,0.9948995,0.00002070077,0.002224025,0.000005743203],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9922516,0.0003293155,0.005805001,0.00003827148,0.0000156503,0.00002207224,0.0003504342,0.0001376055,0.001050023],"genre_scores_gemma":[0.9895606,0.0003070456,0.00509247,0.00005145216,0.000005660583,0.00003930182,0.002198087,0.0001086347,0.002636803],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001118853,"threshold_uncertainty_score":0.003742874,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04865015990353432,"score_gpt":0.2965385028742968,"score_spread":0.2478883429707625,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}