{"id":"W2510035395","doi":"10.3390/ijms17091502","title":"Pharmacogenomics in Pediatric Oncology: Review of Gene—Drug Associations for Clinical Use","year":2016,"lang":"en","type":"review","venue":"International Journal of Molecular Sciences","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine","funders":"","keywords":"Pharmacogenomics; Harmonization; Medicine; Alternative medicine; Pediatric oncology; Personalized medicine; Family medicine; Oncology; Medical education; Bioinformatics; Pharmacology; Internal medicine; Cancer; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002405403,0.0001526224,0.000706583,0.0002200053,0.00002163128,0.00002419522,0.0009131627,0.0001473096,0.000008005065],"category_scores_gemma":[0.0004181251,0.0001119923,0.0007935832,0.0001343211,0.00008553395,0.00001133138,0.00008820819,0.0001403116,0.000001166204],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009993183,"about_ca_system_score_gemma":0.001720739,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002224615,"about_ca_topic_score_gemma":0.000003516265,"domain_scores_codex":[0.9977798,0.0002216056,0.001250531,0.0002325186,0.0003708594,0.0001447007],"domain_scores_gemma":[0.9971781,0.0001852594,0.001864793,0.0001153622,0.0005940839,0.00006244729],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00003631253,0.0002225512,0.00008907936,0.001680184,0.0006172173,0.00002927402,0.00001156168,0.000005766421,0.001559984,0.0003268751,0.001649403,0.9937718],"study_design_scores_gemma":[0.0004743963,0.0002527777,0.000006082229,0.004206521,0.0003454551,0.00005802579,0.000002523157,0.000001416206,0.0008419989,0.0001211209,0.9935529,0.0001368178],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000358942,0.9952264,0.00208024,0.0002333301,0.001566368,0.0002788543,0.0001978895,8.710259e-7,0.00005706095],"genre_scores_gemma":[0.00008855548,0.9956571,0.002906715,0.0005815045,0.0006651575,0.00001410562,0.00003269072,0.00001510854,0.00003901701],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.993635,"threshold_uncertainty_score":0.4566913,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1372055081340066,"score_gpt":0.4937651177257699,"score_spread":0.3565596095917634,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}