{"id":"W2510041615","doi":"10.1021/acsomega.6b00138","title":"Impact of Differential Detergent Interactions on Transmembrane Helix Dimerization Affinities","year":2016,"lang":"en","type":"article","venue":"ACS Omega","topic":"Lipid Membrane Structure and Behavior","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Helix (gastropod); Chemistry; Affinities; Sodium dodecyl sulfate; Transmembrane domain; Transmembrane protein; Micelle; Crystallography; Monomer; Amino acid; Biophysics; Stereochemistry; Biochemistry; Biology; Receptor; Physical chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00001845166,0.0001205175,0.0001153954,0.00005005423,0.00003256058,0.000007530394,0.00009537149,0.00006913288,0.0001210597],"category_scores_gemma":[0.00001979163,0.00007298368,0.0001413205,0.00004309441,0.00004624349,0.000006261953,0.00002010276,0.00003715799,0.000008059335],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001131901,"about_ca_system_score_gemma":0.00003189071,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001369405,"about_ca_topic_score_gemma":0.0000164721,"domain_scores_codex":[0.9994256,0.00002602405,0.0001546754,0.0001684368,0.00008899733,0.0001362315],"domain_scores_gemma":[0.9996197,0.0000134738,0.00005956447,0.0002133356,0.0000470548,0.00004685859],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001645511,0.00007350327,0.001703189,0.000007378419,0.00005436013,4.522786e-7,0.00003665348,0.000005618449,0.990711,0.00003120584,0.0001247904,0.007087251],"study_design_scores_gemma":[0.0005518407,0.0005074939,0.020571,0.00002148704,0.00003240687,0.000005292505,0.000008223323,8.0144e-7,0.9769077,0.000009595964,0.001276451,0.0001076497],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985205,0.00001368336,0.0005222829,0.00006319173,0.000375857,0.00008900244,0.00008236503,0.000009768551,0.0003233583],"genre_scores_gemma":[0.9988,0.00009409442,0.00001965167,0.00002616199,0.0002585925,0.00001126669,0.00008329075,0.00001555825,0.0006913556],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01886781,"threshold_uncertainty_score":0.2976188,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01269861095574013,"score_gpt":0.277113181960907,"score_spread":0.2644145710051669,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}