{"id":"W2510041615","doi":"10.1021/acsomega.6b00138","title":"Impact of Differential Detergent Interactions on Transmembrane Helix Dimerization Affinities","year":2016,"lang":"en","type":"article","venue":"ACS Omega","topic":"Lipid Membrane Structure and Behavior","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Helix (gastropod); Chemistry; Affinities; Sodium dodecyl sulfate; Transmembrane domain; Transmembrane protein; Micelle; Crystallography; Monomer; Amino acid; Biophysics; Stereochemistry; Biochemistry; Biology; Receptor; Physical chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004319444,0.0003239537,0.0002666876,0.000171611,0.0001978215,0.0004894651,0.0002458777,0.0002916068,0.001149888],"category_scores_gemma":[0.0008967949,0.0002067412,0.0001744192,0.0001577679,0.0002708675,0.0003581712,0.0003512947,0.0005182902,0.0002338465],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003988719,"about_ca_system_score_gemma":0.0002562582,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008865319,"about_ca_topic_score_gemma":0.00113699,"domain_scores_codex":[0.9995354,0.0001151272,0.000057357,0.00009327806,0.0001109311,0.00008798914],"domain_scores_gemma":[0.9994507,0.0002363558,0.0001078779,0.00003268067,0.00007082321,0.0001016497],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000152809,0.00002617771,0.0004548713,0.0000200763,0.000007046354,0.00003193768,0.00002030935,0.00009765197,0.9987084,0.00005072906,0.00001030447,0.0004196984],"study_design_scores_gemma":[0.0000151007,0.0001824159,0.003792689,0.000005006174,0.00002004478,0.00008748789,0.00004947797,0.001512603,0.9937931,0.00004586743,0.0004856014,0.00001054168],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989794,0.0002283602,0.0003488606,0.00002042882,0.000006312556,0.000005402831,0.00005342664,0.000008534268,0.0003492799],"genre_scores_gemma":[0.9989631,0.000174566,0.0004721456,0.0000285949,0.000002160981,0.000006195013,0.0001016331,0.000009768102,0.0002419023],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001149888,"threshold_uncertainty_score":0.003846765,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01269861095574013,"score_gpt":0.277113181960907,"score_spread":0.2644145710051669,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}