{"id":"W2510316350","doi":"10.1182/blood.v122.21.172.172","title":"High Content Screening Identifies Synthetic Lethality Of Retinoid Receptor Agonists In IKZF1-Mutated BCR-ABL1 positive Acute Lymphoblastic Leukemia","year":2013,"lang":"en","type":"article","venue":"Blood","topic":"Chronic Myeloid Leukemia Treatments","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"Cancer research; Chronic myelogenous leukemia; Leukemia; Lymphoid leukemia; Biology; CDKN2A; Imatinib; Immunology; Myeloid leukemia; ABL; Philadelphia chromosome; Tyrosine kinase; Chromosomal translocation; Receptor; Genetics; Cancer; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001785643,0.0002827432,0.0002769328,0.0004134489,0.0001126998,0.000229552,0.0002305971,0.0002208934,0.001134697],"category_scores_gemma":[0.0001401562,0.0001163448,0.0001936241,0.0002139328,0.0001539321,0.00006114858,0.0001757764,0.0002180551,0.0004014811],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002139981,"about_ca_system_score_gemma":0.0001178709,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004753307,"about_ca_topic_score_gemma":0.0006429679,"domain_scores_codex":[0.9998548,0.00003401474,0.0000106113,0.0000183023,0.00005159352,0.00003066392],"domain_scores_gemma":[0.9999214,0.00002216336,0.00001816683,0.000009646575,0.000009347142,0.0000193217],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001324977,0.00003404016,0.000251088,0.00001022127,0.000002996942,0.00003592794,0.00000514366,0.00008668454,0.9987746,0.00002570454,0.00001781124,0.0006231854],"study_design_scores_gemma":[0.00002938691,0.000906928,0.004997318,0.000002394881,0.00001695799,0.000347008,0.00002350426,0.001136292,0.9914745,0.00002518483,0.001036848,0.000003689022],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995993,0.0004874693,0.001673097,0.00004783139,0.00001019715,0.00007244392,0.0009099654,0.00006666029,0.0007393798],"genre_scores_gemma":[0.9946409,0.0004169725,0.001962225,0.00003002531,0.000005547983,0.00004899546,0.001470281,0.00001720887,0.001407736],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001134697,"threshold_uncertainty_score":0.003795922,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0162791982280626,"score_gpt":0.2427733639240559,"score_spread":0.2264941656959933,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}