{"id":"W2510334948","doi":"10.1021/acs.jmedchem.6b01033","title":"Discovery of a Potent, Selective, and Cell-Active Dual Inhibitor of Protein Arginine Methyltransferase 4 and Protein Arginine Methyltransferase 6","year":2016,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":86,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Structural Genomics Consortium; University of Toronto","funders":"Structural Genomics Consortium; National Institute of General Medical Sciences; Wellcome Trust; Wellcome; Howard Hughes Medical Institute","keywords":"Chemistry; Arginine; Protein arginine methyltransferase 5; Methyltransferase; Biochemistry; Cell culture; Enzyme; Chemical biology; Epigenetics; Enzyme inhibitor; Structure–activity relationship; In vitro; Amino acid; Methylation; Biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003079277,0.0004458973,0.000424291,0.0002630875,0.0001273197,0.0002288754,0.0004028697,0.000302257,0.0008984031],"category_scores_gemma":[0.0001686597,0.0001775095,0.0002938574,0.0001609947,0.0001811896,0.000228801,0.0002679438,0.0005847536,0.0003727849],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002327075,"about_ca_system_score_gemma":0.0003909756,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003074281,"about_ca_topic_score_gemma":0.000833631,"domain_scores_codex":[0.9998859,0.00001887545,0.00001057125,0.00002226948,0.00003452212,0.00002773253],"domain_scores_gemma":[0.999926,0.0000130918,0.00001949308,0.000007351025,0.00001216667,0.00002184967],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002512033,0.0001639022,0.0004052598,0.00007624365,0.00002212448,0.0001300419,0.00002510382,0.0008778638,0.9883257,0.0004218366,0.0001668005,0.009133837],"study_design_scores_gemma":[0.0001367595,0.001755285,0.0008564733,0.000005519797,0.00003796315,0.0003690988,0.00001086039,0.001628554,0.9884643,0.00007124143,0.006654626,0.000009374718],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9689544,0.005385586,0.02002315,0.0002711147,0.00006619324,0.0002144293,0.0006528165,0.0001758608,0.004256393],"genre_scores_gemma":[0.9754146,0.003714073,0.01528099,0.0001206249,0.00002234986,0.00009381829,0.0009972448,0.00002357106,0.00433265],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008984031,"threshold_uncertainty_score":0.003005445,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004564398290740001,"score_gpt":0.2201110539492775,"score_spread":0.2155466556585375,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}