{"id":"W2510646213","doi":"10.1111/hae.12994","title":"TRUST trial: BAY 86‐6150 use in haemophilia with inhibitors and assessment for immunogenicity","year":2016,"lang":"en","type":"article","venue":"Haemophilia","topic":"Hemophilia Treatment and Research","field":"Medicine","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"Discovery Centre","funders":"Novo Nordisk; Biogen; CSL Behring; Roche; Bayer","keywords":"Immunogenicity; Medicine; Bay; Haemophilia; Immunology; Pediatrics; Antigen; Geography","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001291193,0.0007737707,0.001288706,0.000672868,0.0003150544,0.0001664445,0.0003342437,0.0005253665,0.00003985031],"category_scores_gemma":[0.002002401,0.0004801418,0.000344952,0.0007465793,0.0006060194,0.000602874,0.0002595577,0.0006289327,0.00007677542],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005568812,"about_ca_system_score_gemma":0.0007110461,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000193566,"about_ca_topic_score_gemma":0.0002021832,"domain_scores_codex":[0.994827,0.0002392161,0.0009785796,0.001303951,0.001136612,0.00151467],"domain_scores_gemma":[0.9950208,0.002430385,0.0002791517,0.001133332,0.0004030975,0.0007332023],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00777491,0.003926362,0.8703353,0.0009595783,0.001553614,0.001692446,0.001656977,0.000007093014,0.0424927,0.001809708,0.03666984,0.03112142],"study_design_scores_gemma":[0.2511661,0.01301815,0.4827736,0.002606572,0.001043491,0.0005914231,0.001356691,0.0004422108,0.07055492,0.003856009,0.1719796,0.000611284],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9887795,0.0008316236,0.0001507191,0.002057417,0.0004745311,0.005117267,0.0001514596,0.0001987311,0.002238754],"genre_scores_gemma":[0.9700835,0.0009883393,0.003492989,0.0003024658,0.0008010863,0.000790105,0.0001135769,0.0001900237,0.02323787],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3875618,"threshold_uncertainty_score":0.999765,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0452430128399501,"score_gpt":0.3215325868200062,"score_spread":0.2762895739800562,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}