{"id":"W2510680239","doi":"10.1111/jdv.13918","title":"Apremilast, an oral phosphodiesterase 4 inhibitor, improves patient‐reported outcomes in the treatment of moderate to severe psoriasis: results of two phase <scp>III</scp> randomized, controlled trials","year":2016,"lang":"en","type":"article","venue":"Journal of the European Academy of Dermatology and Venereology","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre de Recherche Dermatologique du Québec Métropolitain","funders":"Baxalta; Celgene; Biogen; Amgen; Pfizer; Eli Lilly and Company","keywords":"Apremilast; Medicine; Psoriasis; Placebo; Dermatology Life Quality Index; Quality of life (healthcare); Internal medicine; Randomized controlled trial; Psoriasis Area and Severity Index; Psoriatic arthritis; Physical therapy; Dermatology; Alternative medicine; Pathology; Nursing","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006846462,0.0009527149,0.002603541,0.0004689568,0.0003213204,0.001064848,0.0007789877,0.001364124,0.00297025],"category_scores_gemma":[0.006047622,0.0004054932,0.003555888,0.0006994242,0.0006833848,0.000581513,0.0002639793,0.001701194,0.0002508302],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005275905,"about_ca_system_score_gemma":0.0009575315,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007964521,"about_ca_topic_score_gemma":0.001981564,"domain_scores_codex":[0.9979231,0.001157683,0.0003372457,0.0001939088,0.0002879506,0.0001001505],"domain_scores_gemma":[0.9962238,0.001702179,0.001268833,0.0001645003,0.0002999057,0.0003408328],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8479302,0.00523911,0.004319884,0.01283451,0.01854994,0.0000627115,0.0001085892,0.0005717906,0.004012351,0.0001272383,0.002839583,0.1034042],"study_design_scores_gemma":[0.9144924,0.05042489,0.0190022,0.0008944516,0.01196963,0.0001064647,0.00003778766,0.0003356488,0.0006860556,0.0001146779,0.001904508,0.00003126859],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8104978,0.1728326,0.001254937,0.002409405,0.0009986238,0.005473288,0.002555771,0.0001926984,0.003784876],"genre_scores_gemma":[0.9284321,0.05923378,0.002413712,0.002126074,0.0010459,0.003584449,0.002031501,0.00003118422,0.001101203],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006846462,"threshold_uncertainty_score":0.03620797,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03281922505732657,"score_gpt":0.3023758425743565,"score_spread":0.2695566175170299,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}