{"id":"W2510680239","doi":"10.1111/jdv.13918","title":"Apremilast, an oral phosphodiesterase 4 inhibitor, improves patient‐reported outcomes in the treatment of moderate to severe psoriasis: results of two phase <scp>III</scp> randomized, controlled trials","year":2016,"lang":"en","type":"article","venue":"Journal of the European Academy of Dermatology and Venereology","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre de Recherche Dermatologique du Québec Métropolitain","funders":"Baxalta; Celgene; Biogen; Amgen; Pfizer; Eli Lilly and Company","keywords":"Apremilast; Medicine; Psoriasis; Placebo; Dermatology Life Quality Index; Quality of life (healthcare); Internal medicine; Randomized controlled trial; Psoriasis Area and Severity Index; Psoriatic arthritis; Physical therapy; Dermatology; Alternative medicine; Pathology; Nursing","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00355249,0.0003629773,0.003965896,0.000321425,0.00009406433,0.000005637035,0.0004304627,0.0002684473,0.000005671131],"category_scores_gemma":[0.002112392,0.0001465021,0.0008146299,0.0001358224,0.0006487329,0.0001241947,0.00007829974,0.0002132259,0.000002597405],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002396002,"about_ca_system_score_gemma":0.00007361452,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002194332,"about_ca_topic_score_gemma":0.00001104467,"domain_scores_codex":[0.9840339,0.01196831,0.003291549,0.0002707168,0.00009943842,0.0003360249],"domain_scores_gemma":[0.9896614,0.006039196,0.003832529,0.0002812476,0.0001306342,0.00005496847],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.5630001,0.006041714,0.03851541,0.00006232573,0.01399215,0.0003147208,0.01671288,0.00008827886,0.2845443,0.0009390821,0.001812889,0.07397622],"study_design_scores_gemma":[0.6590415,0.001202526,0.004800692,0.0001573461,0.002622519,0.002041507,0.0006043572,0.000006098717,0.3272282,0.0008414583,0.001321159,0.0001326262],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9912136,0.005077383,0.00003651771,0.001686231,0.0006948285,0.0009806965,0.00008790012,0.000006953676,0.000215858],"genre_scores_gemma":[0.9979464,0.001406945,0.0001102896,0.0002172579,0.00005782245,0.00002651289,0.000005249884,0.00001757808,0.0002119869],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09604146,"threshold_uncertainty_score":0.5974182,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03281922505732657,"score_gpt":0.3023758425743565,"score_spread":0.2695566175170299,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}