{"id":"W2510705586","doi":"10.1016/j.bmcl.2016.08.063","title":"Design and optimization of (3-aryl-1H-indazol-6-yl)spiro[cyclopropane-1,3′-indolin]-2′-ones as potent PLK4 inhibitors with oral antitumor efficacy","year":2016,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Microtubule and mitosis dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"Canadian Institutes of Health Research; Princess Margaret Cancer Foundation","keywords":"Chemistry; Indazole; In vivo; Cyclopropane; Moiety; Aryl; Stereochemistry; Bioavailability; Pharmacology; In vitro; Biochemistry; Organic chemistry; Ring (chemistry); Alkyl","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002177347,0.0004202486,0.000403192,0.0003142552,0.0001628589,0.0004160715,0.0004815898,0.000177154,0.00188292],"category_scores_gemma":[0.0001513291,0.0002556798,0.0002255823,0.0002346181,0.0001458852,0.0001904393,0.0002357959,0.0004336375,0.0005664797],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004283803,"about_ca_system_score_gemma":0.0005164322,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005424607,"about_ca_topic_score_gemma":0.001976735,"domain_scores_codex":[0.9999025,0.00001450164,0.000009849143,0.00001743608,0.00002484317,0.00003092385],"domain_scores_gemma":[0.9999447,0.000005664353,0.00001880025,0.000004045359,0.00001061584,0.000016207],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001127005,0.0005589661,0.0005708946,0.000445603,0.00004822597,0.0003217438,0.00008700036,0.00750629,0.9491846,0.001671803,0.0008786381,0.03759931],"study_design_scores_gemma":[0.001046411,0.004639244,0.003120684,0.00004391376,0.0002051758,0.0004892107,0.0000462106,0.009028235,0.9523216,0.0002763062,0.02872961,0.00005343237],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9691405,0.007509548,0.0125935,0.0002944608,0.0000925948,0.0004772324,0.001173439,0.0002632091,0.008455565],"genre_scores_gemma":[0.9788964,0.004301471,0.009998373,0.000116635,0.00002156848,0.0002190712,0.001202243,0.00003999991,0.00520417],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00188292,"threshold_uncertainty_score":0.006298959,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006580687069369665,"score_gpt":0.2064847396993319,"score_spread":0.1999040526299622,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}