{"id":"W2510705586","doi":"10.1016/j.bmcl.2016.08.063","title":"Design and optimization of (3-aryl-1H-indazol-6-yl)spiro[cyclopropane-1,3′-indolin]-2′-ones as potent PLK4 inhibitors with oral antitumor efficacy","year":2016,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Microtubule and mitosis dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"Canadian Institutes of Health Research; Princess Margaret Cancer Foundation","keywords":"Chemistry; Indazole; In vivo; Cyclopropane; Moiety; Aryl; Stereochemistry; Bioavailability; Pharmacology; In vitro; Biochemistry; Organic chemistry; Ring (chemistry); Alkyl","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002130964,0.0003431244,0.0003345101,0.00004451524,0.00008214802,0.00001762449,0.0002434569,0.0002110254,0.00006264893],"category_scores_gemma":[0.0000934558,0.0002383581,0.00006691868,0.0001211948,0.0003885752,0.00001221435,0.0001069563,0.0001277355,0.000005471371],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004219983,"about_ca_system_score_gemma":0.0001550928,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002161243,"about_ca_topic_score_gemma":0.000001354583,"domain_scores_codex":[0.998333,0.00003225436,0.0003836503,0.0005777252,0.0002978786,0.0003755244],"domain_scores_gemma":[0.9990298,0.0000309542,0.0002454631,0.0004034297,0.0001008416,0.0001894794],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003810231,0.00009113948,0.0008881082,0.00009230586,0.0001027332,0.00003429079,0.00005188094,0.0001993459,0.9961317,0.000001332654,0.0006341442,0.001392059],"study_design_scores_gemma":[0.002362937,0.000284072,0.0004780075,0.0002043362,0.0001099115,0.0002659775,0.00006013829,0.00006831545,0.9952105,0.000001746634,0.0006048284,0.000349217],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9383391,0.000402115,0.05903021,0.0017667,0.00009090418,0.0003038705,0.00001190251,0.00002667422,0.00002855165],"genre_scores_gemma":[0.995101,0.000458891,0.003289472,0.0005377949,0.0003461344,0.00001320286,0.00007503016,0.0000573614,0.0001210632],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05676197,"threshold_uncertainty_score":0.9719961,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006580687069369665,"score_gpt":0.2064847396993319,"score_spread":0.1999040526299622,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}