{"id":"W2510808283","doi":"10.1177/1087057116666276","title":"A Suite of Biochemical Assays for Screening RNA Methyltransferase BCDIN3D","year":2016,"lang":"en","type":"article","venue":"SLAS DISCOVERY","topic":"RNA modifications and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Structural Genomics Consortium; University of Toronto","funders":"National Institute of General Medical Sciences","keywords":"Suite; Methyltransferase; Computational biology; RNA; Biology; Computer science; Biochemistry; DNA; Geography; Methylation; Gene; Archaeology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001415723,0.002248747,0.001335629,0.002502488,0.000964566,0.0006792902,0.001131867,0.001207532,0.003616964],"category_scores_gemma":[0.001440247,0.0009664513,0.001065014,0.001570472,0.0004841238,0.0003284064,0.001001101,0.001896085,0.003004886],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001107305,"about_ca_system_score_gemma":0.0009661355,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001250442,"about_ca_topic_score_gemma":0.004444405,"domain_scores_codex":[0.9970627,0.0005742105,0.0002918924,0.0004509143,0.001338994,0.0002812796],"domain_scores_gemma":[0.9988216,0.0002351049,0.0001499527,0.000191295,0.0003992463,0.0002028572],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009656297,0.0000845278,0.000402041,0.0001704227,0.00003247396,0.00003931369,0.0000237254,0.0003580463,0.9903013,0.000242933,0.0004794936,0.007769205],"study_design_scores_gemma":[0.00003998398,0.0003595375,0.001263962,0.00001599529,0.00004200988,0.0002466015,0.00001728229,0.00220383,0.986371,0.0001513557,0.009262562,0.00002592952],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.3441491,0.008981004,0.5938268,0.0008008988,0.0004101372,0.004997066,0.01445289,0.009004383,0.02337773],"genre_scores_gemma":[0.2999937,0.007769774,0.6198772,0.0004837749,0.00008824179,0.006609216,0.02881211,0.0006321907,0.03573379],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.003616964,"threshold_uncertainty_score":0.01209992,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01748236853392129,"score_gpt":0.2731006337451269,"score_spread":0.2556182652112057,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}