{"id":"W2510862022","doi":"10.1038/onc.2016.298","title":"Sustained p16INK4a expression is required to prevent IR-induced tumorigenesis in mice","year":2016,"lang":"en","type":"article","venue":"Oncogene","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine","funders":"National Institute on Aging; Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research","keywords":"Carcinogenesis; Biology; Senescence; Cancer research; Context (archaeology); Cell cycle; Cell growth; DNA damage; Stromal cell; Cell biology; Cancer; Genetics; DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002584363,0.0002294598,0.0003734029,0.000247527,0.00004414619,0.000009097337,0.0001577591,0.0001773714,0.0003442378],"category_scores_gemma":[0.0002315398,0.0001708364,0.0001245731,0.0004496167,0.00002092617,0.00006865299,0.0001608754,0.0001068066,0.0002768916],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007590483,"about_ca_system_score_gemma":0.0003555651,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001118803,"about_ca_topic_score_gemma":0.0000612528,"domain_scores_codex":[0.9980906,0.00007963322,0.0004072865,0.0005470152,0.0003973967,0.0004780674],"domain_scores_gemma":[0.9988043,0.0000470133,0.00009683624,0.0005925387,0.0001295534,0.0003298034],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004201708,0.0002166243,0.0001571376,0.00003501841,0.00002599809,0.0002396407,0.0004564269,0.000001872682,0.9634802,0.00001055801,0.004649857,0.03030653],"study_design_scores_gemma":[0.002637123,0.0004462932,0.000667265,0.0006913046,0.00004809175,0.00004076746,0.0001231122,0.000009011648,0.9825913,0.00006630293,0.01244417,0.0002352874],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9900466,0.0004617526,0.0009462199,0.00498855,0.0003202156,0.0009289606,0.00002167744,0.0000928897,0.002193136],"genre_scores_gemma":[0.9931506,0.00009340863,0.001243633,0.0009834877,0.0002329991,0.0001275956,0.00001005569,0.00006760225,0.004090604],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03007125,"threshold_uncertainty_score":0.6966507,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01995195312181177,"score_gpt":0.2862593997240808,"score_spread":0.266307446602269,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}