{"id":"W2510870611","doi":"10.1038/srep31420","title":"Understanding the structural basis of substrate recognition by Plasmodium falciparum plasmepsin V to aid in the design of potent inhibitors","year":2016,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Malaria Research and Control","field":"Medicine","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; University of Guelph","funders":"Natural Sciences and Engineering Research Council of Canada; Indian Institute of Technology Bombay; Canada Research Chairs; Department of Biotechnology, Ministry of Science and Technology, India","keywords":"Pepstatin; Saquinavir; Plasmodium falciparum; Protease; Stereochemistry; Biochemistry; Binding site; Chemistry; Enzyme; Peptide; Biology; Human immunodeficiency virus (HIV); Virology; Antiretroviral therapy; Malaria","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008084928,0.0002963256,0.0002836034,0.00005925972,0.0001608288,0.0003386322,0.0003358499,0.000327534,0.0007970044],"category_scores_gemma":[0.0001402658,0.0001976055,0.0001620086,0.00006195305,0.0001688053,0.0005414597,0.0001639005,0.0004415346,0.0001787714],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003540466,"about_ca_system_score_gemma":0.0004202145,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001420424,"about_ca_topic_score_gemma":0.001407789,"domain_scores_codex":[0.9999708,0.000004573218,0.000001687211,0.000005009709,0.000008328834,0.000009564913],"domain_scores_gemma":[0.9999801,0.000005191249,0.000005959481,0.000001184805,0.000003430539,0.000004172185],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006212787,0.0002535786,0.006765189,0.0006307428,0.00007511857,0.001143623,0.0001921076,0.2640138,0.6774668,0.01782838,0.001404755,0.02960466],"study_design_scores_gemma":[0.0001303601,0.0007173319,0.006262173,0.00005220266,0.00006508807,0.0004337868,0.0002742341,0.8718956,0.1079905,0.006438605,0.005704585,0.00003551235],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9690728,0.003985829,0.02244873,0.0006914944,0.0000276325,0.00005710646,0.0001478474,0.0001280714,0.003440572],"genre_scores_gemma":[0.9917461,0.002655198,0.00495768,0.0000553244,0.000007309994,0.00001929026,0.0001574486,0.000009706822,0.0003919599],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001420424,"threshold_uncertainty_score":0.002824366,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08432554762583622,"score_gpt":0.2846644748746433,"score_spread":0.2003389272488071,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}