{"id":"W2510879407","doi":"10.1182/blood.v112.11.4920.4920","title":"CD19+,CD27+, IgM+ B Cells of Patients with Persistent Polyclonal B Cell (PPBL) Proliferate in a Low Intensity CD40-CD154 Interaction and Show Evidence of Immunoglobulin Isotype Switching","year":2008,"lang":"en","type":"article","venue":"Blood","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Héma-Québec; Université Laval","funders":"","keywords":"CD154; CD19; Biology; CD40; Immunology; Immunoglobulin class switching; B cell; Isotype; Immunoglobulin M; Molecular biology; Antibody; Immunoglobulin G; Genetics; Cytotoxic T cell; Monoclonal antibody; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001825244,0.0007354564,0.0003612528,0.0008726165,0.0004163175,0.0003345435,0.0001958543,0.0006915586,0.004151127],"category_scores_gemma":[0.0006978878,0.00027581,0.0002470948,0.0003423049,0.0003125103,0.0002917653,0.0003260426,0.0004665882,0.0006605054],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001369623,"about_ca_system_score_gemma":0.0001128976,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003704117,"about_ca_topic_score_gemma":0.000281095,"domain_scores_codex":[0.9997937,0.00003644219,0.00002349183,0.00004866906,0.00004323617,0.00005444608],"domain_scores_gemma":[0.9996902,0.00009669868,0.00007013923,0.00002442679,0.00002518207,0.00009336023],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002595159,0.0005355585,0.6546897,0.0004092762,0.0002376105,0.1375576,0.0009441435,0.0002487886,0.162761,0.000478008,0.001518738,0.03802461],"study_design_scores_gemma":[0.0001477731,0.001832804,0.5831765,0.00004554391,0.0001685548,0.3992342,0.0003252382,0.0004441392,0.01156297,0.0002932615,0.002750072,0.00001887304],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970292,0.000634843,0.0003024861,0.00007446104,0.00001247394,0.00001730441,0.00008794052,0.00004678912,0.001794524],"genre_scores_gemma":[0.9993587,0.0001222326,0.00008238118,0.00004550636,0.00002472883,0.000007862415,0.00008962968,0.000005348918,0.0002635534],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004151127,"threshold_uncertainty_score":0.01388693,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01129481702017754,"score_gpt":0.1975544614285416,"score_spread":0.186259644408364,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}