{"id":"W2511032019","doi":"10.1007/s10545-016-9973-6","title":"Impact of long‐term elosulfase alfa treatment on respiratory function in patients with Morquio A syndrome","year":2016,"lang":"en","type":"article","venue":"Journal of Inherited Metabolic Disease","topic":"Lysosomal Storage Disorders Research","field":"Medicine","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Children's Hospital; Hospital for Sick Children","funders":"National Institutes of Health; University of California, San Francisco; Fondazione Pierfranco e Luisa Mariani; Sarepta Therapeutics; National Center for Advancing Translational Sciences; BioMarin Pharmaceutical; Alexion Pharmaceuticals; Amicus Therapeutics; Teva Pharmaceutical Industries","keywords":"Medicine; Enzyme replacement therapy; Regimen; Population; Respiratory system; Internal medicine; Vital capacity; Placebo; Pulmonary function testing; Surgery; Diffusing capacity; Lung; Lung function; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001203093,0.0004290941,0.0008507452,0.0001193838,0.0001910254,0.0003968766,0.0002470147,0.0004072772,0.0007845015],"category_scores_gemma":[0.0009322797,0.000107867,0.0008317647,0.00009978606,0.0002565122,0.000323786,0.000221039,0.0006383011,0.0001036599],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000304377,"about_ca_system_score_gemma":0.000327226,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003190083,"about_ca_topic_score_gemma":0.0005837988,"domain_scores_codex":[0.9995989,0.000237525,0.00003956377,0.0000416841,0.00003650177,0.00004583262],"domain_scores_gemma":[0.9991199,0.0002370599,0.0002711223,0.0000449285,0.00004386731,0.0002831372],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.5969147,0.01399765,0.1311549,0.0009572961,0.002999302,0.0009071021,0.0002337075,0.001849157,0.08247388,0.00018594,0.001155574,0.1671708],"study_design_scores_gemma":[0.06763317,0.5684099,0.3508777,0.0001226501,0.001279616,0.001000946,0.0002216566,0.002208387,0.006153339,0.0001374667,0.001910512,0.00004470009],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980237,0.001516285,0.00008320679,0.00006768368,0.00001578552,0.00003884438,0.0000576852,0.000004696763,0.0001919983],"genre_scores_gemma":[0.9992286,0.0002590978,0.000130514,0.00009635189,0.00002600312,0.00003631259,0.0001248379,8.855552e-7,0.00009740615],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001203093,"threshold_uncertainty_score":0.006362617,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02200778418672216,"score_gpt":0.3037329672488506,"score_spread":0.2817251830621284,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}