{"id":"W2511116949","doi":"10.1371/journal.pbio.1002534","title":"Polarized Exocytosis Induces Compensatory Endocytosis by Sec4p-Regulated Cortical Actin Polymerization","year":2016,"lang":"en","type":"article","venue":"PLoS Biology","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Cancer Society Research Institute; Michael Smith Health Research BC","keywords":"Endocytosis; Exocytosis; Cell biology; Biology; MDia1; Actin remodeling; Wiskott–Aldrich syndrome protein; Actin; Rab; Actin remodeling of neurons; Vesicle fusion; Cell polarity; Actin cytoskeleton; GTPase; Cytoskeleton; Vesicle; Biochemistry; Cell; Secretion; Membrane","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001116971,0.0004068732,0.0002747544,0.0002056026,0.0001291746,0.0004806148,0.0001948011,0.0002067463,0.0009146782],"category_scores_gemma":[0.0001205537,0.0002563474,0.0002845557,0.0001701686,0.0002708929,0.0001754368,0.0004585992,0.0003639046,0.0004877123],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000406428,"about_ca_system_score_gemma":0.0002084033,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002630923,"about_ca_topic_score_gemma":0.0003454009,"domain_scores_codex":[0.9998407,0.00002605754,0.00001045721,0.00003079701,0.00004508982,0.00004678429],"domain_scores_gemma":[0.9998633,0.00002573543,0.00003740968,0.00002417537,0.00001754967,0.00003186965],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006116326,0.000007078034,0.0001814791,0.00001535436,0.000003363809,0.0001073751,0.000004577538,0.00009728322,0.9987959,0.0001658999,0.00003507908,0.0005254692],"study_design_scores_gemma":[0.00001236479,0.00002772267,0.002567902,0.000002236224,0.000005503736,0.0001763669,0.00001359631,0.002055593,0.9939978,0.0000842859,0.001053088,0.0000036193],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955605,0.0002866354,0.002687382,0.00005739283,0.0000165359,0.0000102632,0.0001068189,0.0001141676,0.001160333],"genre_scores_gemma":[0.9970933,0.0002459204,0.0009967842,0.00002409603,0.000004587083,0.00001576339,0.0001836045,0.00003407961,0.001401693],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009146782,"threshold_uncertainty_score":0.003059924,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01325561216908775,"score_gpt":0.2259755610216111,"score_spread":0.2127199488525233,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}