{"id":"W2511171894","doi":"10.3233/jad-160458","title":"Profiling of p5, a 24 Amino Acid Inhibitory Peptide Derived from the CDK5 Activator, p35 CDKR1 Against 70 Protein Kinases","year":2016,"lang":"en","type":"article","venue":"Journal of Alzheimer s Disease","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Kinexus Bioinformatics Corporation (Canada)","funders":"National Institutes of Health","keywords":"Cyclin-dependent kinase 5; Kinase; Activator (genetics); Biology; Cell biology; Phosphorylation; Cyclin-dependent kinase; Hyperphosphorylation; Cyclin-dependent kinase 2; Biochemistry; Molecular biology; Protein kinase A; Cell cycle; Cell; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000176774,0.000434926,0.0002496894,0.0004462939,0.0001767426,0.0002843064,0.0001532353,0.0002094331,0.0004822805],"category_scores_gemma":[0.0002066537,0.0001045131,0.000295203,0.0003865997,0.0001294823,0.0001843632,0.0001193308,0.0002786923,0.0002675703],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002311238,"about_ca_system_score_gemma":0.0001870169,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000871543,"about_ca_topic_score_gemma":0.001187291,"domain_scores_codex":[0.9998651,0.00001995219,0.00001320105,0.00003116516,0.00004179301,0.00002879968],"domain_scores_gemma":[0.9998959,0.0000249865,0.00002557899,0.000008977238,0.00002531317,0.0000192056],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001059385,0.00002226933,0.000701636,0.00004861749,0.000008163609,0.00004815527,0.00001182245,0.0002529183,0.9965177,0.00002732612,0.00004178562,0.002213578],"study_design_scores_gemma":[0.00000753732,0.0005997465,0.01355313,0.000007145508,0.00004617591,0.0006701403,0.00003416932,0.001309413,0.9804246,0.00003119729,0.00330969,0.000007121786],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9894086,0.003950897,0.004054917,0.00005070768,0.00001342845,0.00006584359,0.001177369,0.00005238407,0.001225849],"genre_scores_gemma":[0.9865812,0.003290673,0.005228973,0.00005588751,0.0000119394,0.00004927871,0.003122087,0.00002605826,0.001633845],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000871543,"threshold_uncertainty_score":0.001732945,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02461527835464587,"score_gpt":0.2546558495552059,"score_spread":0.23004057120056,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}