{"id":"W2511197283","doi":"10.1021/acs.jmedchem.6b00867","title":"Hybrid Antibiotic Overcomes Resistance in <i>P. aeruginosa</i> by Enhancing Outer Membrane Penetration and Reducing Efflux","year":2016,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":72,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Natural Sciences and Engineering Research Council of Canada; Institute of Infection and Immunity; Canadian Institutes of Health Research; Manitoba Health Research Council","keywords":"Efflux; Pseudomonas aeruginosa; Tobramycin; Microbiology; Colistin; Chemistry; Antibiotics; Moxifloxacin; Bacterial outer membrane; Multiple drug resistance; Pharmacology; Multidrug tolerance; Bacteria; Biology; Gentamicin; Escherichia coli; Biofilm; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005579471,0.0001785108,0.0003030183,0.00003547372,0.0000355487,0.00002236351,0.0001888676,0.0001225074,0.000032646],"category_scores_gemma":[0.0003985296,0.0001286807,0.00006424309,0.00005140266,0.0001468431,0.00002205579,0.00004149852,0.0001674587,9.588028e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006476045,"about_ca_system_score_gemma":0.0001212933,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004386389,"about_ca_topic_score_gemma":0.000009472893,"domain_scores_codex":[0.998579,0.00004425193,0.00057895,0.0002652789,0.0002869283,0.0002455726],"domain_scores_gemma":[0.9991024,0.0000629467,0.0003915002,0.0002130145,0.0001026288,0.0001275662],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002260349,0.00003250208,0.008559755,0.0001678341,0.00002791036,0.00006198385,0.00002780502,6.485051e-7,0.9870995,0.000001892848,0.003165761,0.0006284239],"study_design_scores_gemma":[0.001275248,0.00009046374,0.005556914,0.001063935,0.00002530952,0.0003812574,0.00006976179,0.000001240936,0.9890328,0.00003329723,0.002307216,0.0001625293],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946652,0.003043725,0.0006758237,0.0006756251,0.0001634666,0.00005507197,0.000008879852,0.000003403084,0.0007087714],"genre_scores_gemma":[0.9962298,0.001514619,0.0006897383,0.0001091884,0.0004820333,3.989977e-7,0.00000774995,0.00001853803,0.0009479153],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003002841,"threshold_uncertainty_score":0.5247447,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004336203570398326,"score_gpt":0.2255057910098368,"score_spread":0.2211695874394384,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}