{"id":"W2511197283","doi":"10.1021/acs.jmedchem.6b00867","title":"Hybrid Antibiotic Overcomes Resistance in <i>P. aeruginosa</i> by Enhancing Outer Membrane Penetration and Reducing Efflux","year":2016,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":72,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Natural Sciences and Engineering Research Council of Canada; Institute of Infection and Immunity; Canadian Institutes of Health Research; Manitoba Health Research Council","keywords":"Efflux; Pseudomonas aeruginosa; Tobramycin; Microbiology; Colistin; Chemistry; Antibiotics; Moxifloxacin; Bacterial outer membrane; Multiple drug resistance; Pharmacology; Multidrug tolerance; Bacteria; Biology; Gentamicin; Escherichia coli; Biofilm; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007142773,0.0002332395,0.0002425007,0.0001578602,0.0000932324,0.0003044115,0.0002185246,0.0002483949,0.000752456],"category_scores_gemma":[0.00009014353,0.0001019298,0.0002146031,0.000121029,0.0001562431,0.0001757018,0.000240408,0.0003757222,0.0002247757],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002194456,"about_ca_system_score_gemma":0.0001007024,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003299885,"about_ca_topic_score_gemma":0.0006645518,"domain_scores_codex":[0.9999192,0.00001507367,0.000006282299,0.0000161037,0.0000229613,0.00002027143],"domain_scores_gemma":[0.9999473,0.000005393196,0.00001991808,0.000007047563,0.000007805363,0.00001255052],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004096545,0.00002647146,0.0001547925,0.00001721564,0.000007142706,0.00003010285,0.000005853651,0.0001097959,0.9981743,0.00006200038,0.00002639705,0.001345026],"study_design_scores_gemma":[0.00001340918,0.0006477092,0.002796579,0.000005382049,0.00002423503,0.0004316168,0.00001591734,0.0007537271,0.9924045,0.0000332579,0.002865738,0.000007859519],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951337,0.0006367734,0.002567253,0.00008325197,0.00001077871,0.00002126762,0.00009946866,0.00007934418,0.001368174],"genre_scores_gemma":[0.9946978,0.0003313054,0.003740274,0.00005041209,0.000004450597,0.00001282648,0.0001735485,0.00001746244,0.0009717709],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000752456,"threshold_uncertainty_score":0.002517164,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004336203570398326,"score_gpt":0.2255057910098368,"score_spread":0.2211695874394384,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}