{"id":"W2511313493","doi":"10.1016/j.ebiom.2016.08.012","title":"Genetic Risk Can Be Decreased: Quitting Smoking Decreases and Delays Lung Cancer for Smokers With High and Low CHRNA5 Risk Genotypes — A Meta-Analysis","year":2016,"lang":"en","type":"review","venue":"EBioMedicine","topic":"Smoking Behavior and Cessation","field":"Medicine","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"Public Health Ontario; Sinai Health System; Lunenfeld-Tanenbaum Research Institute","funders":"National Center for Advancing Translational Sciences; National Center for Research Resources; National Institute of Dental and Craniofacial Research; National Institute of Environmental Health Sciences; National Institute of General Medical Sciences; National Cancer Institute; National Institute on Drug Abuse; Imperial Experimental Cancer Medicine Centre; Mayo Foundation for Medical Education and Research; Deutsche Forschungsgemeinschaft; Georg-August-Universität Göttingen; Canadian Cancer Society Research Institute; Jonsson Comprehensive Cancer Center; National Institutes of Health; Radboud Universiteit; Bundesamt für Strahlenschutz; University of California, San Francisco; Cancer Prevention and Research Institute of Texas; Norges Forskningsråd; Helmholtz Zentrum München; Bundesministerium für Bildung und Forschung; Deutsches Krebsforschungszentrum; California Department of Public Health; Radboud Universitair Medisch Centrum; Centers for Disease Control and Prevention; Deutsche Krebshilfe; National Natural Science Foundation of China; Mayo Clinic; National Heart, Lung, and Blood Institute; University of Texas MD Anderson Cancer Center; Cancer Care Ontario","keywords":"Lung cancer; Medicine; Smoking cessation; Genotype; Internal medicine; Meta-analysis; Oncology; Cancer; Genetics; Pathology; Biology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0009079242,0.0008125289,0.004221478,0.0009852489,0.0003441975,0.00005734251,0.0001517547,0.0003782451,0.0003490998],"category_scores_gemma":[0.0003554317,0.0004492298,0.0008335876,0.0008978665,0.000342142,0.00006163587,0.00006526237,0.0004164043,2.279923e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002845966,"about_ca_system_score_gemma":0.0004831465,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01013452,"about_ca_topic_score_gemma":0.0008147107,"domain_scores_codex":[0.9964966,0.0002301521,0.000941235,0.001079923,0.0006790421,0.000573004],"domain_scores_gemma":[0.9964079,0.0008835233,0.001253211,0.0006542939,0.0002544116,0.0005466528],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.000177689,0.00008523968,0.1163935,0.01131438,0.1809741,0.0001177278,0.0003714192,0.000003367188,0.000007310596,0.000009042245,0.0003726186,0.6901736],"study_design_scores_gemma":[0.002491701,0.0004154616,0.01728179,0.00493261,0.9364755,0.0001437615,0.00008239783,0.00005835012,0.00001278838,0.00001344664,0.03747572,0.0006164742],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0473344,0.9479066,0.001330468,0.0002188127,0.0001241078,0.001757354,0.001242679,0.00007547882,0.00001011756],"genre_scores_gemma":[0.03935365,0.9573547,0.0008457734,0.0001763436,0.0005916443,0.0008231299,0.0005779183,0.0001390359,0.0001378083],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.7555014,"threshold_uncertainty_score":0.999796,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04862324527851689,"score_gpt":0.3515074950039042,"score_spread":0.3028842497253873,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}