{"id":"W2511313493","doi":"10.1016/j.ebiom.2016.08.012","title":"Genetic Risk Can Be Decreased: Quitting Smoking Decreases and Delays Lung Cancer for Smokers With High and Low CHRNA5 Risk Genotypes — A Meta-Analysis","year":2016,"lang":"en","type":"review","venue":"EBioMedicine","topic":"Smoking Behavior and Cessation","field":"Medicine","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"Public Health Ontario; Sinai Health System; Lunenfeld-Tanenbaum Research Institute","funders":"National Center for Advancing Translational Sciences; National Center for Research Resources; National Institute of Dental and Craniofacial Research; National Institute of Environmental Health Sciences; National Institute of General Medical Sciences; National Cancer Institute; National Institute on Drug Abuse; Imperial Experimental Cancer Medicine Centre; Mayo Foundation for Medical Education and Research; Deutsche Forschungsgemeinschaft; Georg-August-Universität Göttingen; Canadian Cancer Society Research Institute; Jonsson Comprehensive Cancer Center; National Institutes of Health; Radboud Universiteit; Bundesamt für Strahlenschutz; University of California, San Francisco; Cancer Prevention and Research Institute of Texas; Norges Forskningsråd; Helmholtz Zentrum München; Bundesministerium für Bildung und Forschung; Deutsches Krebsforschungszentrum; California Department of Public Health; Radboud Universitair Medisch Centrum; Centers for Disease Control and Prevention; Deutsche Krebshilfe; National Natural Science Foundation of China; Mayo Clinic; National Heart, Lung, and Blood Institute; University of Texas MD Anderson Cancer Center; Cancer Care Ontario","keywords":"Lung cancer; Medicine; Smoking cessation; Genotype; Internal medicine; Meta-analysis; Oncology; Cancer; Genetics; Pathology; Biology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.007735608,0.002558625,0.008152056,0.002587422,0.0005730756,0.002696533,0.001870142,0.002864925,0.004611108],"category_scores_gemma":[0.01621153,0.001550768,0.04907103,0.002542783,0.0006008504,0.001372347,0.001227992,0.002893788,0.0004007182],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001284262,"about_ca_system_score_gemma":0.001476821,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.008798624,"about_ca_topic_score_gemma":0.01297125,"domain_scores_codex":[0.9937405,0.003489746,0.0009590593,0.001008235,0.0004973851,0.0003049465],"domain_scores_gemma":[0.9922032,0.005530951,0.001044729,0.0004895186,0.0004347865,0.0002966847],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"meta_analysis","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.01474288,0.00008530637,0.0122066,0.02880929,0.9270931,0.0001442245,0.00006144833,0.0008749904,0.0005370399,0.0001416009,0.000678681,0.01462483],"study_design_scores_gemma":[0.002042939,0.0004451358,0.0071879,0.001735282,0.9869415,0.00007092344,0.00002575892,0.0003417929,0.0001086912,0.0002147648,0.0008651678,0.00002017468],"study_design_candidate":"meta_analysis","study_design_consensus":"meta_analysis","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.06288264,0.9309849,0.001669937,0.001221038,0.0007160167,0.0002314099,0.001038343,0.0001382226,0.001117401],"genre_scores_gemma":[0.8473404,0.145005,0.002597442,0.002019662,0.0006609358,0.0003029362,0.001151118,0.00007284591,0.0008498365],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.008798624,"threshold_uncertainty_score":0.0409103,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04862324527851689,"score_gpt":0.3515074950039042,"score_spread":0.3028842497253873,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}