{"id":"W2511558499","doi":"10.1186/s12885-016-2748-5","title":"Promoter hypermethylation of HS3ST2, SEPTIN9 and SLIT2 combined with FGFR3 mutations as a sensitive/specific urinary assay for diagnosis and surveillance in patients with low or high-risk non-muscle-invasive bladder cancer","year":2016,"lang":"en","type":"article","venue":"BMC Cancer","topic":"Bladder and Urothelial Cancer Treatments","field":"Medicine","cited_by":88,"is_retracted":false,"has_abstract":true,"ca_institutions":"Cytodiagnostics (Canada)","funders":"Assistance publique-Hôpitaux de Paris; Bpifrance","keywords":"Bladder cancer; Medicine; DNA methylation; Oncology; Internal medicine; Methylation; Logistic regression; Area under the curve; Epigenetics; Multiplex; Cancer; Bioinformatics; Biology; Gene; Gene expression; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000117834,0.0002506241,0.0004473748,0.0001166268,0.00007580738,0.00001252156,0.00003229385,0.00008497226,0.0001274836],"category_scores_gemma":[0.00006868943,0.0001421215,0.00003582872,0.0002114294,0.0001758094,0.0001497081,0.00002185398,0.00007668032,0.00000145287],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001722895,"about_ca_system_score_gemma":0.0003674953,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001157782,"about_ca_topic_score_gemma":0.004842126,"domain_scores_codex":[0.9986826,0.00008812037,0.0002532596,0.0004687235,0.0002482589,0.000259092],"domain_scores_gemma":[0.9986327,0.0004972349,0.0002028831,0.0002016248,0.0003498336,0.0001157223],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.006932161,0.0004254736,0.9716392,0.000223636,0.0002352497,0.00001285473,0.0008083235,0.00001360639,0.0002742073,0.000005738304,0.0001177391,0.01931183],"study_design_scores_gemma":[0.01870894,0.004053972,0.9722666,0.0008595541,0.0001836185,0.000005172193,0.0001229409,0.00002423231,0.003406694,0.00003299411,0.0001081213,0.0002271809],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956985,0.0003129891,0.0003725706,0.0003030104,0.00007199328,0.002250417,0.0009254031,0.0000197175,0.00004539795],"genre_scores_gemma":[0.9960977,0.0007969384,0.001115313,0.00008043523,0.00007903622,0.001384109,0.00005078753,0.00005264875,0.0003429627],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01908465,"threshold_uncertainty_score":0.5795548,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01274315741948845,"score_gpt":0.2612102364889259,"score_spread":0.2484670790694375,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}