{"id":"W2511558499","doi":"10.1186/s12885-016-2748-5","title":"Promoter hypermethylation of HS3ST2, SEPTIN9 and SLIT2 combined with FGFR3 mutations as a sensitive/specific urinary assay for diagnosis and surveillance in patients with low or high-risk non-muscle-invasive bladder cancer","year":2016,"lang":"en","type":"article","venue":"BMC Cancer","topic":"Bladder and Urothelial Cancer Treatments","field":"Medicine","cited_by":88,"is_retracted":false,"has_abstract":true,"ca_institutions":"Cytodiagnostics (Canada)","funders":"Assistance publique-Hôpitaux de Paris; Bpifrance","keywords":"Bladder cancer; Medicine; DNA methylation; Oncology; Internal medicine; Methylation; Logistic regression; Area under the curve; Epigenetics; Multiplex; Cancer; Bioinformatics; Biology; Gene; Gene expression; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009271419,0.0002958685,0.0002996298,0.0007786928,0.0001241074,0.0003113547,0.0002414509,0.0003367214,0.0004578594],"category_scores_gemma":[0.002141103,0.0001948063,0.0002604289,0.0003486791,0.0001992601,0.0001489486,0.0002179815,0.000247062,0.0001577043],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001934215,"about_ca_system_score_gemma":0.0001814953,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007760992,"about_ca_topic_score_gemma":0.001566731,"domain_scores_codex":[0.9994251,0.0002262076,0.00004913506,0.0001158487,0.0001490794,0.00003483367],"domain_scores_gemma":[0.9989246,0.0004277724,0.000328109,0.00005380114,0.0001349174,0.0001308057],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0006012234,0.00004683237,0.9862605,0.00001836124,0.0000562026,0.00008123385,0.00004573433,0.0002627117,0.009026828,0.00001289947,0.00006251893,0.003524908],"study_design_scores_gemma":[0.00004223162,0.0006423463,0.9742993,0.00001221257,0.0001332342,0.001439291,0.00006704484,0.009424397,0.01357014,0.0000487856,0.0003111273,0.000009928491],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986985,0.000473018,0.0004492109,0.00002549926,0.000004543024,0.000008723225,0.0001156428,0.00001436179,0.0002104715],"genre_scores_gemma":[0.9991601,0.00006344569,0.0005638815,0.00001038206,0.000005713554,0.000006628914,0.0001122436,0.000001257263,0.00007629982],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009271419,"threshold_uncertainty_score":0.004903197,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01274315741948845,"score_gpt":0.2612102364889259,"score_spread":0.2484670790694375,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}