{"id":"W2511688731","doi":"10.1530/rep-16-0254","title":"Activin A-induced increase in LOX activity in human granulosa–lutein cells is mediated by CTGF","year":2016,"lang":"en","type":"article","venue":"Reproduction","topic":"Connective Tissue Growth Factor Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"Child and Family Research Institute; University of British Columbia","funders":"Canadian Institutes of Health Research","keywords":"CTGF; Lysyl oxidase; Cell biology; Activin type 2 receptors; Downregulation and upregulation; Elastin; Extracellular matrix; Chemistry; Theca; Gene knockdown; Ovarian follicle; Endocrinology; Internal medicine; Granulosa cell; Small interfering RNA; Ovary; Biology; Transforming growth factor; Growth factor; Receptor; TGF beta signaling pathway; Cell culture; Transfection; Medicine; Biochemistry; Apoptosis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006887477,0.0001772025,0.0001875199,0.0001806979,0.00004931454,0.00001488911,0.0001586537,0.0001925344,0.00009439635],"category_scores_gemma":[0.0005371448,0.0001561096,0.00005167346,0.00028327,0.00006618688,0.00002370396,0.0001161779,0.0001826827,0.00003808777],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001664162,"about_ca_system_score_gemma":0.00006840308,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001639218,"about_ca_topic_score_gemma":0.0006699947,"domain_scores_codex":[0.997952,0.0003111612,0.0002044485,0.0009561311,0.0002170193,0.0003592512],"domain_scores_gemma":[0.9990221,0.0000339395,0.00008228561,0.00070023,0.0000726389,0.0000888034],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002009932,0.0002269931,0.01107725,0.00001359631,0.00001396533,0.000005549899,0.00004648617,3.637994e-7,0.9736755,0.000003339455,0.001199574,0.01353636],"study_design_scores_gemma":[0.000926597,0.0001909575,0.03523215,0.00002101542,0.000003032712,0.00000391228,0.00001610064,0.000003147067,0.9590018,0.00007160296,0.004333741,0.0001959896],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979537,0.00009501317,0.00004712198,0.001136271,0.0001119924,0.0004037579,0.00003129186,0.0000200485,0.0002007808],"genre_scores_gemma":[0.9986476,0.00008400789,0.000009240849,0.00002005524,0.000198035,0.00005588403,0.00003919899,0.0000285446,0.0009174502],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0241549,"threshold_uncertainty_score":0.6365964,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01879629953137286,"score_gpt":0.2931624629437686,"score_spread":0.2743661634123957,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}