{"id":"W2511905967","doi":"10.1182/blood.v124.21.2109.2109","title":"Phase 1b/2 Study of Carfilzomib, Pomalidomide, and Dexamethasone (KPd) in Patients (Pts) with Lenalidomide-Exposed and/or -Refractory but Proteasome Inhibitor (PI)-Naive or -Sensitive Multiple Myeloma: A Multiple Myeloma Research Consortium Multi-Center Study","year":2014,"lang":"en","type":"article","venue":"Blood","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto","funders":"","keywords":"Pomalidomide; Lenalidomide; Carfilzomib; Medicine; Internal medicine; Regimen; Discontinuation; Refractory (planetary science); Bortezomib; Population; Multiple myeloma; Dexamethasone; Daratumumab; Phases of clinical research; Gastroenterology; Oncology; Pharmacology; Toxicity; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002856125,0.002062312,0.002549572,0.0005684483,0.0006947125,0.001364544,0.001099058,0.001483054,0.004152141],"category_scores_gemma":[0.001121117,0.001095599,0.002196854,0.0006884161,0.00118047,0.001164461,0.0006148191,0.003897785,0.0009563281],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001476386,"about_ca_system_score_gemma":0.002747294,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001468138,"about_ca_topic_score_gemma":0.00313317,"domain_scores_codex":[0.9990579,0.0004425348,0.000050815,0.000172555,0.0001013972,0.0001747985],"domain_scores_gemma":[0.9989383,0.00009289839,0.0001683376,0.00007663186,0.00007438586,0.0006494563],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.7665173,0.1513764,0.01725369,0.0005608491,0.001596198,0.0003011879,0.0002872881,0.001447344,0.0226678,0.0002237707,0.002261135,0.0355071],"study_design_scores_gemma":[0.5563256,0.4185875,0.01903407,0.00002495079,0.0007010415,0.0002612783,0.00008390599,0.0006334324,0.002202578,0.0001821227,0.001928487,0.00003509069],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.991097,0.0009628602,0.0003846159,0.0004727631,0.00007401356,0.004773702,0.001255135,0.00004315526,0.0009367891],"genre_scores_gemma":[0.9864402,0.001025675,0.002053344,0.000983589,0.0002023131,0.005200306,0.002206563,0.0000236445,0.001864321],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004152141,"threshold_uncertainty_score":0.01510477,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06087972045998236,"score_gpt":0.3409894979192949,"score_spread":0.2801097774593125,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}