{"id":"W2511927595","doi":"10.1007/s12079-016-0346-6","title":"CCN family of proteins: critical modulators of the tumor cell microenvironment","year":2016,"lang":"en","type":"article","venue":"Journal of Cell Communication and Signaling","topic":"Connective Tissue Growth Factor Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":68,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children","funders":"","keywords":"CYR61; CTGF; Extracellular matrix; Matricellular protein; Cell biology; Tumor microenvironment; Context (archaeology); Secretion; Metastasis; Biology; Cancer cell; Tumor progression; Chemistry; Cancer; Bioinformatics; Biochemistry; Receptor; Growth factor; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004279042,0.00005920871,0.0001193429,0.00003334374,0.00004617343,0.00000571865,0.0003112683,0.00003643931,0.00001885158],"category_scores_gemma":[0.0001345111,0.00003570566,0.00007811872,0.00003567108,0.0001894575,0.000005960082,0.0001726653,0.00009657368,4.193699e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001317673,"about_ca_system_score_gemma":0.00004750428,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000560576,"about_ca_topic_score_gemma":8.338267e-7,"domain_scores_codex":[0.999165,0.0002155499,0.000305802,0.00006601038,0.0001663452,0.00008128998],"domain_scores_gemma":[0.9991461,0.00009668637,0.0002478448,0.0003139271,0.0001511313,0.00004428331],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005118703,0.00007769452,0.002440096,0.00003422122,0.00001110137,2.711329e-7,0.0000654049,0.000007965646,0.9968137,0.00003860038,0.0000267763,0.0004330381],"study_design_scores_gemma":[0.000435398,0.0001804732,0.004874434,0.00008914412,0.0000120482,0.000005168033,0.0001570028,0.00001046632,0.99297,0.0001694676,0.001053734,0.00004266578],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945667,0.00356928,0.001278082,0.0002652022,0.0000160519,0.0000954241,0.000004256942,5.13061e-7,0.0002044869],"genre_scores_gemma":[0.9983894,0.0004608834,0.001038272,0.00002712203,0.00001691296,0.000001609274,4.174938e-7,0.000007215966,0.00005814365],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003843646,"threshold_uncertainty_score":0.1456035,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01485681988350082,"score_gpt":0.2586859446716413,"score_spread":0.2438291247881405,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}