{"id":"W2511927825","doi":"10.1038/srep32259","title":"A-Disintegrin and Metalloproteinase (ADAM) 17 Enzymatically Degrades Interferon-gamma","year":2016,"lang":"en","type":"article","venue":"Scientific Reports","topic":"HER2/EGFR in Cancer Research","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"First Quantum Minerals (Canada)","funders":"National Institute of Dental and Craniofacial Research; Japan Science and Technology Agency; National Institutes of Health; Astellas Foundation for Research on Metabolic Disorders; Ministry of Education, Culture, Sports, Science and Technology; Japan Society for the Promotion of Science; Astellas Pharma","keywords":"Disintegrin; Metalloproteinase; Cancer research; Interferon gamma; Osteolysis; Cytokine; Cancer cell; Immune system; Cell culture; Interferon; Cancer; Chemistry; Biology; Immunology; Matrix metalloproteinase; Medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002910006,0.0005692401,0.0003679952,0.0003116074,0.0001933792,0.0004083556,0.0001605258,0.0002521199,0.001057913],"category_scores_gemma":[0.0002112511,0.000162625,0.0005710726,0.0001996149,0.0002970109,0.0002318857,0.0002796694,0.0005483293,0.0004441144],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002135202,"about_ca_system_score_gemma":0.0002632336,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002745997,"about_ca_topic_score_gemma":0.0002823825,"domain_scores_codex":[0.9998042,0.00003884138,0.00003403719,0.00003194852,0.00004442971,0.00004653016],"domain_scores_gemma":[0.9998618,0.00001847041,0.00005823854,0.00001619953,0.00002040433,0.00002479608],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003108208,0.00004837446,0.001989598,0.0002459154,0.00003878873,0.0004323678,0.00004093406,0.0001453969,0.984876,0.0003147818,0.0002075818,0.01134941],"study_design_scores_gemma":[0.00006384819,0.0006674921,0.01112062,0.00004626236,0.00009001137,0.002768098,0.00009899033,0.001156982,0.9649476,0.0003569776,0.01867212,0.00001103544],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9474528,0.03020792,0.01631876,0.0004169215,0.0002274573,0.0001508219,0.001006751,0.0002309315,0.003987497],"genre_scores_gemma":[0.9753645,0.01297123,0.005770582,0.0001402495,0.000056381,0.00009638833,0.0007941235,0.00001895502,0.004787531],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001057913,"threshold_uncertainty_score":0.003539085,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03702278482390364,"score_gpt":0.3247247182860958,"score_spread":0.2877019334621922,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}