{"id":"W2511958569","doi":"10.1021/acsinfecdis.5b00011","title":"Alternative Pathway to a Glycopeptide-Resistant Cell Wall in the Balhimycin Producer <i>Amycolatopsis balhimycina</i>","year":2015,"lang":"en","type":"article","venue":"ACS Infectious Diseases","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Canadian Institutes of Health Research; Canada Research Chairs; Deutsche Forschungsgemeinschaft","keywords":"Peptidoglycan; Glycopeptide; Biology; Biochemistry; Mutant; Glycopeptide antibiotic; Lipid II; Cell wall; Microbiology; Bacteria; Gene; Vancomycin; Genetics; Antibiotics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004712555,0.0003262256,0.0004183032,0.0002062129,0.0001178531,0.00009926841,0.0002891374,0.00009026805,0.00008889788],"category_scores_gemma":[0.001114123,0.0002010559,0.0001409004,0.0008065236,0.00007185716,0.0001574893,0.0001197633,0.0002917837,0.0002661142],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002881307,"about_ca_system_score_gemma":0.0003130485,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001200938,"about_ca_topic_score_gemma":0.0003773501,"domain_scores_codex":[0.9978112,0.0002084754,0.0003790641,0.0006336121,0.0004929413,0.000474699],"domain_scores_gemma":[0.9983679,0.0001609257,0.0001149099,0.0006844332,0.0003031675,0.0003686584],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.006602546,0.0108957,0.1621128,0.001069945,0.0005189251,0.002049873,0.01240353,0.0003523687,0.4217956,0.002368632,0.3534588,0.02637123],"study_design_scores_gemma":[0.01025602,0.005418031,0.08737704,0.0008700261,0.001027105,0.0004153528,0.002339388,0.00006644999,0.4329961,0.003508632,0.4535712,0.002154619],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9834926,0.001097039,0.000006474452,0.004039614,0.0003207244,0.001597919,0.00008793642,0.0001211802,0.009236541],"genre_scores_gemma":[0.9910033,0.00006059912,0.00006464394,0.00706148,0.0005224097,0.00004188576,0.0000294096,0.00003904341,0.001177263],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1001124,"threshold_uncertainty_score":0.8198823,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01628707344632634,"score_gpt":0.2502485573396486,"score_spread":0.2339614838933223,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}