{"id":"W2511958569","doi":"10.1021/acsinfecdis.5b00011","title":"Alternative Pathway to a Glycopeptide-Resistant Cell Wall in the Balhimycin Producer <i>Amycolatopsis balhimycina</i>","year":2015,"lang":"en","type":"article","venue":"ACS Infectious Diseases","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Canadian Institutes of Health Research; Canada Research Chairs; Deutsche Forschungsgemeinschaft","keywords":"Peptidoglycan; Glycopeptide; Biology; Biochemistry; Mutant; Glycopeptide antibiotic; Lipid II; Cell wall; Microbiology; Bacteria; Gene; Vancomycin; Genetics; Antibiotics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001270677,0.0004426689,0.0003790816,0.0001376221,0.0001743381,0.0006150992,0.000315951,0.0005298667,0.0005543969],"category_scores_gemma":[0.0001531573,0.0001647239,0.0003380005,0.000169679,0.000208086,0.0002171579,0.0004750596,0.0007829358,0.0006223486],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003694278,"about_ca_system_score_gemma":0.0002450272,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001058886,"about_ca_topic_score_gemma":0.0007617529,"domain_scores_codex":[0.999835,0.00002853643,0.0000172529,0.00004250031,0.00004834198,0.00002820971],"domain_scores_gemma":[0.999892,0.00002231384,0.00003449186,0.00001764816,0.00001536947,0.00001819265],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002152932,0.00001010545,0.0001064317,0.0000198787,0.000001605471,0.00006425618,0.00001241558,0.00003343131,0.9990594,0.00005852579,0.00001161424,0.0006009312],"study_design_scores_gemma":[0.00001081471,0.0001334997,0.004374571,0.00001471612,0.00001367917,0.000535615,0.00009048972,0.001477154,0.9894314,0.0000763042,0.00382761,0.00001413932],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9908828,0.0008155941,0.005060883,0.0001910455,0.00003715873,0.00004972189,0.0005730407,0.0002138207,0.002175773],"genre_scores_gemma":[0.9877732,0.0003747691,0.005816944,0.00008477264,0.000006368331,0.00004943254,0.001226646,0.00006388451,0.004603995],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001058886,"threshold_uncertainty_score":0.002680421,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01628707344632634,"score_gpt":0.2502485573396486,"score_spread":0.2339614838933223,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}