{"id":"W2512042252","doi":"10.1016/j.jtho.2016.08.139","title":"An Anaplastic Lymphoma Kinase Immunohistochemistry–Negative but Fluorescence In Situ Hybridization–Positive Lung Adenocarcinoma Is Resistant to Crizotinib","year":2016,"lang":"en","type":"article","venue":"Journal of Thoracic Oncology","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":false,"ca_institutions":"University Health Network; Princess Margaret Cancer Centre; University of Toronto","funders":"National Cancer Institute; Canadian Cancer Society Research Institute","keywords":"Crizotinib; Anaplastic lymphoma kinase; ALK inhibitor; Fluorescence in situ hybridization; Cancer research; Lung cancer; Immunohistochemistry; Fusion gene; Medicine; Adenocarcinoma; Tyrosine-kinase inhibitor; Molecular biology; In situ hybridization; Cancer; Biology; Pathology; Gene expression; Gene; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001975829,0.0005056149,0.0004615035,0.0006102526,0.0005574463,0.001009549,0.0004825433,0.001117289,0.002126207],"category_scores_gemma":[0.0008361676,0.0002411148,0.0006452872,0.0004809045,0.0004627368,0.0003236425,0.000209534,0.0007849524,0.0005523981],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007981723,"about_ca_system_score_gemma":0.0003534956,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003089285,"about_ca_topic_score_gemma":0.006637848,"domain_scores_codex":[0.9997383,0.00002238444,0.00002836348,0.00005921863,0.00006115084,0.00009066738],"domain_scores_gemma":[0.9995896,0.0001049369,0.00007882647,0.00003104952,0.00004983267,0.0001456672],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"case_report","study_design_gemma":"case_report","study_design_scores_codex":[0.002263339,0.0003312107,0.1279935,0.0001574223,0.0002187755,0.613532,0.0002664624,0.000459432,0.2248539,0.0007811562,0.003387794,0.02575497],"study_design_scores_gemma":[0.0001281238,0.0008896475,0.2785313,0.00003492004,0.0003409358,0.6852811,0.0005320064,0.002065743,0.02093535,0.0006680331,0.01055015,0.00004270214],"study_design_candidate":"case_report","study_design_consensus":"case_report","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9875524,0.001730686,0.0005203434,0.001723203,0.0001350061,0.0000442698,0.000480689,0.00006625459,0.007747156],"genre_scores_gemma":[0.9980573,0.0003291869,0.0002762676,0.0002298034,0.00004342796,0.000003813766,0.0001807172,0.00001353927,0.0008659523],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003089285,"threshold_uncertainty_score":0.00711292,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01211312311629011,"score_gpt":0.3967490528495426,"score_spread":0.3846359297332526,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}