{"id":"W2512044461","doi":"","title":"A human monoclonal IgG that binds aβ assemblies and diverse amyloids exhibits anti-amyloid activities in vitro and in vivo","year":2015,"lang":"en","type":"article","venue":"PMC","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Trinity College","funders":"","keywords":"Amyloid (mycology); In vivo; Epitope; Antibody; P3 peptide; In vitro; Amyloidosis; Monoclonal antibody; Genetically modified mouse; Chemistry; Amyloid precursor protein; Alzheimer's disease; Immunology; Molecular biology; Biology; Biochemistry; Transgene; Medicine; Pathology; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003785639,0.0002178647,0.0004436742,0.0004267764,0.00008511993,0.00005936308,0.00008970869,0.0001161756,0.00006955232],"category_scores_gemma":[0.00005807491,0.0001809223,0.00004473068,0.0002264393,0.0002716641,0.0002411659,0.0002348923,0.0003594667,0.000009148916],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007112798,"about_ca_system_score_gemma":0.00009306017,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00132997,"about_ca_topic_score_gemma":0.0003657638,"domain_scores_codex":[0.9984546,0.00008237251,0.0002133218,0.0003552265,0.0004545852,0.0004398585],"domain_scores_gemma":[0.9993584,0.0001099358,0.00004552672,0.0001532753,0.00004290812,0.0002899524],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0009204316,0.0002070782,0.7547284,0.0001592251,0.00003627223,0.0003784307,0.001859212,0.000002060154,0.238026,0.0001170979,0.000929558,0.002636247],"study_design_scores_gemma":[0.004760754,0.0005506873,0.8169519,0.0002720462,0.00003103476,0.0002363762,0.00433727,0.0003770572,0.167038,0.0004583729,0.004565517,0.0004209974],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9930366,0.001283264,0.000001224374,0.000957789,0.00005821274,0.0002416022,0.00003718509,0.00002538791,0.004358779],"genre_scores_gemma":[0.9958037,0.0004209154,0.0002130807,0.0001630722,0.0001203327,0.00002170692,0.00001400876,0.00001960917,0.00322356],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07098798,"threshold_uncertainty_score":0.7377796,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06567409398542898,"score_gpt":0.327761980672181,"score_spread":0.262087886686752,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}