{"id":"W2512165727","doi":"10.1371/journal.pone.0161158","title":"IGF1R Derived PI3K/AKT Signaling Maintains Growth in a Subset of Human T-Cell Acute Lymphoblastic Leukemias","year":2016,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Acute Lymphoblastic Leukemia research","field":"Medicine","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; BC Cancer Agency","funders":"Canadian Institutes of Health Research; Terry Fox Foundation; Leukemia and Lymphoma Society of Canada; Leukemia and Lymphoma Society","keywords":"PTEN; Insulin-like growth factor 1 receptor; PI3K/AKT/mTOR pathway; Protein kinase B; Biology; Cancer research; Signal transduction; MAPK/ERK pathway; Cell growth; Context (archaeology); Receptor tyrosine kinase; clone (Java method); Cell biology; Growth factor; Receptor; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004536432,0.0003450905,0.0008963952,0.0005411523,0.0000793753,0.00001787654,0.0003933154,0.0002463159,0.0004820568],"category_scores_gemma":[0.0006705642,0.0002588121,0.0001429985,0.0005896731,0.0003426135,0.0001565822,0.0002274158,0.0002869701,0.0001941386],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002279457,"about_ca_system_score_gemma":0.001115412,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002599386,"about_ca_topic_score_gemma":0.00004032096,"domain_scores_codex":[0.9964718,0.0001476519,0.000759793,0.000588201,0.001148665,0.0008838971],"domain_scores_gemma":[0.9977385,0.0006980837,0.0002146429,0.0005827101,0.0003869921,0.0003790923],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006644613,0.001845752,0.01671823,0.0005428353,0.0004453539,0.0005132854,0.0004187138,0.000001643441,0.9782529,0.0002590014,0.0002319855,0.0001058383],"study_design_scores_gemma":[0.01496038,0.001309283,0.004613705,0.002205703,0.0005112782,0.00004289545,0.0001556667,0.0004663141,0.9746839,0.0007107775,0.000005791281,0.0003342704],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957318,0.00007037264,0.0008126432,0.0005559012,0.00002355937,0.000741874,0.00006337079,0.00009881581,0.001901652],"genre_scores_gemma":[0.9957895,0.00009491002,0.002098618,0.0002192807,0.0001647467,0.0000828835,0.00003881392,0.00009828781,0.001413017],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01429592,"threshold_uncertainty_score":0.9999864,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03517265468727535,"score_gpt":0.2615973434544876,"score_spread":0.2264246887672123,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}