{"id":"W2512219735","doi":"10.3791/54486","title":"Evaluation of the Efficacy And Toxicity of RNAs Targeting HIV-1 Production for Use in Gene or Drug Therapy","year":2016,"lang":"en","type":"article","venue":"Journal of Visualized Experiments","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research","keywords":"Ribozyme; Biology; Small interfering RNA; RNA interference; RNA; DNA-directed RNA interference; Computational biology; Genetic enhancement; Viral replication; Small nucleolar RNA; Small hairpin RNA; Gene; Long non-coding RNA; Virology; Virus; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001383757,0.0006680205,0.0006100577,0.0004470087,0.0004303601,0.000501249,0.0003824557,0.0005841617,0.001609472],"category_scores_gemma":[0.0009363676,0.0002400697,0.0004974242,0.000418103,0.0004074905,0.0003807921,0.0001984465,0.000805055,0.0004059569],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004445789,"about_ca_system_score_gemma":0.0003481633,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007457876,"about_ca_topic_score_gemma":0.0008207354,"domain_scores_codex":[0.999111,0.000283216,0.00009867939,0.0001074239,0.0003135364,0.00008616636],"domain_scores_gemma":[0.9991568,0.0004064577,0.0001086815,0.00009145372,0.0001933787,0.00004320083],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001659584,0.0001826543,0.0001986347,0.0001062578,0.00001353932,0.00002720634,0.00003601864,0.0004464852,0.9947978,0.00008294108,0.00007988981,0.00386271],"study_design_scores_gemma":[0.00001116057,0.002211495,0.0008183111,0.000007194239,0.00002699843,0.00005094651,0.00001089827,0.0006313861,0.9955239,0.00002799215,0.0006733674,0.000006431106],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9583227,0.006585214,0.02746612,0.0001447461,0.0001223856,0.00105117,0.001557422,0.0002557038,0.00449461],"genre_scores_gemma":[0.9366918,0.008472349,0.04299968,0.0001249941,0.00007331451,0.001122029,0.00293282,0.0001413989,0.007441492],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001609472,"threshold_uncertainty_score":0.007318079,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0887499732952295,"score_gpt":0.4437070555012596,"score_spread":0.3549570822060301,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}