{"id":"W2512221405","doi":"10.1016/j.colsurfb.2016.08.035","title":"Achieving high gene delivery performance with caveolae-mediated endocytosis pathway by (l)-arginine/(l)-histidine co-modified cationic gene carriers","year":2016,"lang":"en","type":"article","venue":"Colloids and Surfaces B Biointerfaces","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal","funders":"Youth Innovation Promotion Association; National Science Foundation; Youth Innovation Promotion Association of the Chinese Academy of Sciences; Donghua University; National Natural Science Foundation of China; Chinese Academy of Sciences","keywords":"Gene delivery; Endocytosis; Transfection; Chemistry; Biochemistry; Cytotoxicity; Arginine; Histidine; Biophysics; Molecular biology; Biology; In vitro; Amino acid; Cell; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002035925,0.0004158189,0.0003694856,0.00008501237,0.0002735011,0.00009707733,0.0003287538,0.0001995491,0.00005417381],"category_scores_gemma":[0.00004162775,0.0002840789,0.00007259185,0.0001453659,0.0003321671,0.00004364473,0.0001320873,0.0001068997,0.00002491326],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005450871,"about_ca_system_score_gemma":0.0001603916,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001914233,"about_ca_topic_score_gemma":0.000138467,"domain_scores_codex":[0.9980527,0.00008040689,0.0003791819,0.0007417058,0.0002315127,0.0005144557],"domain_scores_gemma":[0.998917,0.00005124096,0.0001884919,0.0004264009,0.0002024407,0.0002143977],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004484745,0.00004292858,0.02216914,0.0000267256,0.0001772193,0.000004307032,0.00007339652,0.00009150156,0.9728534,0.00000257264,0.001987444,0.002122864],"study_design_scores_gemma":[0.001471294,0.001380615,0.004704831,0.00008953458,0.00004297227,0.00003249357,0.0001269431,0.000135492,0.9829667,0.00000169686,0.008523633,0.0005237753],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932586,0.004329665,0.0006853678,0.0002700374,0.0001762342,0.0002904361,0.0006378733,0.00004455527,0.000307223],"genre_scores_gemma":[0.9890448,0.006875211,0.0003724218,0.0001458397,0.00008301676,0.00004756813,0.0003214348,0.00004477513,0.003064865],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01746431,"threshold_uncertainty_score":0.9999611,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006672245790583054,"score_gpt":0.200324117865243,"score_spread":0.1936518720746599,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}