{"id":"W2512246276","doi":"10.3998/ark.5550190.0002.612","title":"Synthesis and evaluation of 3-substituted-4-oxa-1-azabicyclo[3,2,0]heptan-7-ones as cysteine proteases inhibitors: part II","year":2001,"lang":"en","type":"article","venue":"ARKIVOC","topic":"Click Chemistry and Applications","field":"Chemistry","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"NAEJA-RGM Pharmaceuticals (Canada)","funders":"","keywords":"Chemistry; Proteases; Cysteine; Combinatorial chemistry; Stereochemistry; Pharmacology; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001413541,0.0003736063,0.0003921223,0.0001952191,0.00018627,0.000273083,0.000256126,0.0002008304,0.001466717],"category_scores_gemma":[0.0001092362,0.0001381938,0.0001865651,0.0001576628,0.0001767551,0.0001490356,0.0001473216,0.0003874351,0.000450676],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002806494,"about_ca_system_score_gemma":0.0004149853,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000959239,"about_ca_topic_score_gemma":0.001444781,"domain_scores_codex":[0.9998959,0.00001789455,0.000006503954,0.00001331746,0.00003300307,0.00003332644],"domain_scores_gemma":[0.9999448,0.000007022334,0.00001294294,0.000004944954,0.000009784698,0.00002039892],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002046202,0.00007649518,0.00009336496,0.000123463,0.000009328766,0.0001089599,0.00002531936,0.0004182875,0.9885384,0.0003229739,0.0001427075,0.009936147],"study_design_scores_gemma":[0.00004941118,0.001139168,0.00110261,0.000007790254,0.0000181257,0.0002742069,0.00001017689,0.0004179613,0.9914263,0.00004665392,0.005495326,0.00001228861],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9731063,0.009945647,0.007325212,0.0001406368,0.000116764,0.0003289618,0.0005754976,0.0001630392,0.008297834],"genre_scores_gemma":[0.9764498,0.0067972,0.008090611,0.00009093841,0.00003665578,0.0001581229,0.0007793199,0.00002548353,0.007571808],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001466717,"threshold_uncertainty_score":0.004906654,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02909320672420191,"score_gpt":0.2850325435756905,"score_spread":0.2559393368514886,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}