{"id":"W2512388909","doi":"10.1016/j.jagp.2016.08.018","title":"Enhanced Molecular Aging in Late-Life Depression: the Senescent-Associated Secretory Phenotype","year":2016,"lang":"en","type":"article","venue":"American Journal of Geriatric Psychiatry","topic":"Telomeres, Telomerase, and Senescence","field":"Medicine","cited_by":68,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"National Institute of Mental Health; National Institute on Aging","keywords":"Comorbidity; Depression (economics); Internal medicine; Cognition; Phenotype; Body mass index; Correlation; Late life depression; Medicine; Clinical psychology; Psychology; Psychiatry; Biology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002329326,0.0002598282,0.0002656076,0.0003276258,0.0001358774,0.0003709026,0.0001464637,0.0002821753,0.0007755414],"category_scores_gemma":[0.0005370104,0.0001053198,0.000169853,0.0002295853,0.0001508799,0.0002411603,0.0002298385,0.0003985391,0.0001398434],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001631564,"about_ca_system_score_gemma":0.000153939,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004031144,"about_ca_topic_score_gemma":0.0006669606,"domain_scores_codex":[0.9999566,0.000009657259,0.000005641491,0.000007682884,0.00001237906,0.000008090834],"domain_scores_gemma":[0.999796,0.0000175422,0.0000902257,0.00001834949,0.00003369473,0.00004423276],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.006647732,0.0005181381,0.4407244,0.0004111739,0.0002686934,0.00526657,0.0009293926,0.0002916715,0.4419434,0.002015278,0.001827461,0.09915614],"study_design_scores_gemma":[0.00006512002,0.001048653,0.9800094,0.00004988137,0.00009716392,0.006122658,0.000268059,0.0004746634,0.008908499,0.001002841,0.001939842,0.00001317029],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937975,0.004211447,0.0005096165,0.0002330366,0.00003427518,0.00001432534,0.0001680234,0.00001674925,0.001014998],"genre_scores_gemma":[0.9972008,0.001690782,0.000287503,0.00007731754,0.00004157561,0.000007180879,0.0001242884,0.000003588038,0.0005669431],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007755414,"threshold_uncertainty_score":0.002594471,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005651642521179463,"score_gpt":0.2434561912162821,"score_spread":0.2378045486951026,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}