{"id":"W2512442926","doi":"10.1038/nchembio.2166","title":"Covalent targeting of remote cysteine residues to develop CDK12 and CDK13 inhibitors","year":2016,"lang":"en","type":"article","venue":"Nature Chemical Biology","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":372,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Cancer Institute; Medical Research Council; Ministero dello Sviluppo Economico; Ontario Genomics Institute; Hope Funds for Cancer Research; Diamond Light Source; National Human Genome Research Institute; Wellcome Trust; National Institutes of Health; Ontario Genomics; Genome Canada; Ontario Ministry of Economic Development and Innovation; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology; Deutsche Forschungsgemeinschaft; Dana-Farber/Harvard Cancer Center; GlaxoSmithKline; Pfizer; Eli Lilly and Company","keywords":"Kinase; Enhancer; Cell biology; Biology; Transcription factor; Cyclin-dependent kinase; Processivity; Gene expression; Transcription (linguistics); Gene; Chemistry; Molecular biology; Genetics; Polymerase; Cell cycle","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005339544952155734,"score_gpt":0.2519261609122563,"score_spread":0.2465866159601005,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}