{"id":"W2512569256","doi":"10.2196/resprot.6046","title":"Preventing Paradoxical Tuberculosis-Associated Immune Reconstitution Inflammatory Syndrome in High-Risk Patients: Protocol of a Randomized Placebo-Controlled Trial of Prednisone (PredART Trial)","year":2016,"lang":"en","type":"article","venue":"JMIR Research Protocols","topic":"Infectious Diseases and Tuberculosis","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Francis Crick Institute; Wellcome Trust","keywords":"Prednisone; Medicine; Randomized controlled trial; Placebo; Tuberculosis; Immunology; Protocol (science); Immune system; Immune reconstitution inflammatory syndrome; Internal medicine; Physical therapy; Alternative medicine; Human immunodeficiency virus (HIV); Pathology; Viral load","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.01125995,0.0003613872,0.002707557,0.0008154131,0.0001645398,0.00003706246,0.0002793773,0.0004369162,0.0003390707],"category_scores_gemma":[0.01226154,0.0002302414,0.001017055,0.0007393837,0.000703826,0.0003119053,0.0001831534,0.000670964,0.00002317328],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004949407,"about_ca_system_score_gemma":0.0009458999,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001963323,"about_ca_topic_score_gemma":0.00002554363,"domain_scores_codex":[0.9882821,0.005550184,0.003054789,0.0005920419,0.001701631,0.0008192038],"domain_scores_gemma":[0.9941124,0.00237112,0.001380453,0.0007675664,0.00111591,0.0002524908],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9671046,0.01236473,0.01488262,0.001094183,0.0006698435,0.00001923877,0.00009790091,0.000002235731,0.000703994,0.0003628509,0.00008660006,0.002611219],"study_design_scores_gemma":[0.9675993,0.01231956,0.00852106,0.00863226,0.0001246352,0.000003930679,0.00001646343,0.00006357834,0.001505245,0.000876289,0.0001141364,0.0002234907],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"protocol","genre_gemma":"protocol","genre_scores_codex":[0.4565907,0.00000152766,0.000009789796,0.00007248786,0.00001798604,0.5429046,0.00002795127,0.00004065118,0.000334427],"genre_scores_gemma":[0.4170149,0.000002295299,0.00002792752,0.000002592544,0.00005350053,0.5827385,0.00001021383,0.00002794478,0.0001221936],"genre_candidate":"protocol","genre_consensus":"protocol","teacher_disagreement_score":0.03983394,"threshold_uncertainty_score":0.9960586,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03440348391400348,"score_gpt":0.4020479881297525,"score_spread":0.367644504215749,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}