{"id":"W2512582262","doi":"10.1038/nature19804","title":"Diversity-oriented synthesis yields novel multistage antimalarial inhibitors","year":2016,"lang":"en","type":"article","venue":"Nature","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":266,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Victoria","funders":"National Institute of General Medical Sciences; National Institutes of Health; Global Health Innovative Technology Fund; Medicines for Malaria Venture; Wellcome Trust; National Institute of Allergy and Infectious Diseases; Bill and Melinda Gates Foundation","keywords":"Bicyclic molecule; Malaria; Drug discovery; Antimalarial Agent; Drug development; Biology; Natural product; Computational biology; Drug; Pharmacology; Chemistry; Stereochemistry; Plasmodium falciparum; Bioinformatics; Biochemistry; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009541542,0.0001326674,0.0001421601,0.0000321464,0.0001917233,0.000009064732,0.0001899341,0.001070521,0.000117875],"category_scores_gemma":[0.0005607058,0.00008808509,0.0001884673,0.00009463848,0.00005947276,0.000004223532,0.0004627937,0.0002678295,0.00001112814],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001608613,"about_ca_system_score_gemma":0.0000140406,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000020958,"about_ca_topic_score_gemma":0.00001580481,"domain_scores_codex":[0.999155,0.00001779891,0.0001170422,0.0003410056,0.0001741985,0.0001949319],"domain_scores_gemma":[0.9994962,0.00004588856,0.00005587572,0.0002536621,0.0000659338,0.00008243055],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005924091,0.00006828505,0.007985358,0.000004491204,0.0000786426,0.000002720034,0.000008926394,3.270179e-7,0.9841896,0.00008797936,0.004047754,0.003466662],"study_design_scores_gemma":[0.0003714342,0.00002080087,0.002707982,0.00002650586,0.00005119342,0.000002085759,0.00001172323,0.000005407669,0.9165739,0.000008111448,0.08004854,0.0001723629],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958612,0.0002234375,0.001604151,0.0011597,0.0002110962,0.00005683069,0.0001083201,0.00001968583,0.0007556273],"genre_scores_gemma":[0.9978035,0.00006430841,0.0004451486,0.000267791,0.0004973456,0.000003698388,0.00001734417,0.00001251914,0.0008883589],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07600079,"threshold_uncertainty_score":0.8256837,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005079806518027162,"score_gpt":0.2171431341325371,"score_spread":0.2120633276145099,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}