{"id":"W2512596660","doi":"10.1016/j.ijcard.2016.08.273","title":"Efficacy of alirocumab in high cardiovascular risk populations with or without heterozygous familial hypercholesterolemia: Pooled analysis of eight ODYSSEY Phase 3 clinical program trials","year":2016,"lang":"en","type":"article","venue":"International Journal of Cardiology","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":60,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Université du Québec à Chicoutimi","funders":"Regeneron Pharmaceuticals; Sanofi","keywords":"Medicine; Alirocumab; Familial hypercholesterolemia; PCSK9; Internal medicine; Pooled analysis; Clinical trial; Atherosclerotic cardiovascular disease; Meta-analysis; Oncology; Cholesterol; LDL receptor; Lipoprotein; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01695313,0.001513169,0.006323853,0.001410799,0.0003288961,0.001721676,0.0005604404,0.0009229167,0.001678519],"category_scores_gemma":[0.01609227,0.0007828966,0.01187365,0.001707212,0.0004666877,0.0008008105,0.001100681,0.0008547726,0.0001593522],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005902765,"about_ca_system_score_gemma":0.001034671,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009140971,"about_ca_topic_score_gemma":0.003195887,"domain_scores_codex":[0.9899629,0.006879073,0.001336169,0.000835544,0.0007529698,0.0002333818],"domain_scores_gemma":[0.9902367,0.005145902,0.002887034,0.0006920564,0.0007002625,0.000338118],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"meta_analysis","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.3123095,0.0002848336,0.04033883,0.02159336,0.5684276,0.0001706181,0.0001648201,0.001556287,0.003975026,0.0001201475,0.001462749,0.04959613],"study_design_scores_gemma":[0.1106041,0.01355097,0.1207827,0.001801502,0.7461529,0.0003915839,0.0001111739,0.001268913,0.001212986,0.0004620417,0.003562032,0.00009895294],"study_design_candidate":"meta_analysis","study_design_consensus":"meta_analysis","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6184844,0.3681184,0.003830653,0.0007536974,0.0002791645,0.001856711,0.004255453,0.0002106276,0.002210928],"genre_scores_gemma":[0.9632431,0.03085515,0.002021251,0.0005167465,0.0001675374,0.0009791264,0.001803993,0.00004091936,0.0003721546],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01695313,"threshold_uncertainty_score":0.08965778,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08081113192650478,"score_gpt":0.4276831968868014,"score_spread":0.3468720649602966,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}