{"id":"W2512614248","doi":"10.1016/j.virol.2016.08.024","title":"HIV-1 tat protein recruits CIS to the cytoplasmic tail of CD127 to induce receptor ubiquitination and proteasomal degradation","year":2016,"lang":"en","type":"article","venue":"Virology","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":3,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"Canadian Institutes of Health Research","keywords":"Interleukin-7 receptor; Biology; Cell biology; Ubiquitin; Receptor; Proteasome; Phosphorylation; CD8; Cytolysis; Cytoplasm; Ubiquitin ligase; Protein degradation; Molecular biology; Cytotoxic T cell; T cell; Immune system; Biochemistry; Immunology; IL-2 receptor; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002408203,0.0003664706,0.0001807404,0.0002111029,0.0003925608,0.0005237168,0.0001406703,0.0002266368,0.002996749],"category_scores_gemma":[0.0001739655,0.000183643,0.0003720061,0.0001221308,0.0001872919,0.0003172265,0.0004030552,0.0008306555,0.0007710213],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007077361,"about_ca_system_score_gemma":0.0004158831,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004909484,"about_ca_topic_score_gemma":0.001136493,"domain_scores_codex":[0.9997321,0.00004080182,0.0000128926,0.00003790453,0.00006128947,0.0001150818],"domain_scores_gemma":[0.9998462,0.00002189673,0.00003724319,0.00001948547,0.00002866102,0.00004652776],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000319167,0.00003874295,0.0008894586,0.00005003312,0.00001286238,0.0001427833,0.00003480213,0.0001395225,0.9939929,0.0005040717,0.0002668131,0.003608703],"study_design_scores_gemma":[0.00002819862,0.0001818009,0.008268469,0.00001438905,0.00001089098,0.0007269175,0.0001306459,0.001427949,0.9855325,0.0001976034,0.003471682,0.00000898954],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9921843,0.001688809,0.002853467,0.0001711247,0.00005421602,0.00003252606,0.0001711811,0.00006316481,0.002781325],"genre_scores_gemma":[0.9951544,0.0003747658,0.001042336,0.00004637422,0.000009752944,0.00001343557,0.0002871753,0.00001740673,0.003054447],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002996749,"threshold_uncertainty_score":0.01002508,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01831937748246658,"score_gpt":0.2524396669498212,"score_spread":0.2341202894673546,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}