{"id":"W2512614248","doi":"10.1016/j.virol.2016.08.024","title":"HIV-1 tat protein recruits CIS to the cytoplasmic tail of CD127 to induce receptor ubiquitination and proteasomal degradation","year":2016,"lang":"en","type":"article","venue":"Virology","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":3,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"Canadian Institutes of Health Research","keywords":"Interleukin-7 receptor; Biology; Cell biology; Ubiquitin; Receptor; Proteasome; Phosphorylation; CD8; Cytolysis; Cytoplasm; Ubiquitin ligase; Protein degradation; Molecular biology; Cytotoxic T cell; T cell; Immune system; Biochemistry; Immunology; IL-2 receptor; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0003204749,0.0001160136,0.0001767874,0.0001348206,0.0001178661,0.000005982174,0.0001560937,0.0001590143,0.0003686091],"category_scores_gemma":[0.0003642083,0.00006519841,0.00002588288,0.0001336033,0.00013964,0.00005993007,0.0001120884,0.0001100562,0.002534456],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004939308,"about_ca_system_score_gemma":0.00005743223,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005256781,"about_ca_topic_score_gemma":0.0001282756,"domain_scores_codex":[0.9987863,0.0003825288,0.0001937758,0.0002769982,0.00004453777,0.0003158126],"domain_scores_gemma":[0.9994342,0.0001420863,0.00007140078,0.0002231096,0.00008261279,0.00004664138],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005247309,0.00006735316,0.001075119,0.000006735143,0.00004778663,0.00000193284,0.0002732891,3.632786e-7,0.9210292,0.0008151685,0.003611797,0.07254658],"study_design_scores_gemma":[0.001641752,0.002307025,0.02466138,0.00004539422,0.00001453232,0.0000424674,0.00008078812,4.538404e-7,0.8245539,0.0001524398,0.1463726,0.0001272701],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9787025,0.0001477968,0.0009479835,0.01811232,0.00009174729,0.001573063,0.0001472212,0.00002372156,0.0002536467],"genre_scores_gemma":[0.992905,0.00001694118,0.000328295,0.0001818784,0.00002481872,0.0006951916,0.00005772808,0.00001049006,0.00577965],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1427608,"threshold_uncertainty_score":0.9982422,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01831937748246658,"score_gpt":0.2524396669498212,"score_spread":0.2341202894673546,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}