{"id":"W2512634905","doi":"10.1074/jbc.m116.738849","title":"Early Growth Response 1 (Egr-1) Is a Transcriptional Activator of β-Secretase 1 (BACE-1) in the Brain","year":2016,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"Alzheimer's Society","keywords":"Amyloid precursor protein; Amyloid precursor protein secretase; Chemistry; Activator (genetics); Hippocampal formation; Gene knockdown; Cell biology; Cleavage (geology); Pathogenesis; Transcription factor; Biochemistry; Alzheimer's disease; Neuroscience; Biology; Internal medicine; Apoptosis; Gene; Medicine; Disease; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001613768,0.0009532456,0.0004061268,0.0004285401,0.000242035,0.0004808055,0.0002834777,0.0004536432,0.001171502],"category_scores_gemma":[0.0001360902,0.000187816,0.0005397458,0.0003450643,0.0002975794,0.0002853019,0.0003570484,0.000891963,0.001020388],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005113364,"about_ca_system_score_gemma":0.0002424859,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000721385,"about_ca_topic_score_gemma":0.0005616037,"domain_scores_codex":[0.9998298,0.00001870502,0.00001213746,0.00005079517,0.00005184792,0.00003674514],"domain_scores_gemma":[0.9999093,0.000008435354,0.00003800671,0.000007773213,0.00001762751,0.00001880019],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001407403,0.00004161481,0.0007901421,0.0001807303,0.00001765722,0.0002371291,0.00004039186,0.000143299,0.9916703,0.0003049643,0.0002697606,0.00616335],"study_design_scores_gemma":[0.00003219341,0.000370001,0.0162203,0.00005709514,0.00008156458,0.001363907,0.0001450669,0.001030002,0.9593461,0.0003985243,0.02093528,0.00001999592],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9164964,0.05890168,0.01427467,0.001090623,0.0003492322,0.000111478,0.002474274,0.0008339443,0.005467724],"genre_scores_gemma":[0.9446681,0.02891589,0.007990241,0.0004983068,0.00009149785,0.000105785,0.003856473,0.00006729509,0.01380652],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001171502,"threshold_uncertainty_score":0.003919065,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04702647408683598,"score_gpt":0.3153572547024209,"score_spread":0.2683307806155849,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}