{"id":"W2512802152","doi":"10.1093/protein/gzw043","title":"Isolation of TGF-β-neutralizing single-domain antibodies of predetermined epitope specificity using next-generation DNA sequencing","year":2016,"lang":"en","type":"article","venue":"Protein Engineering Design and Selection","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph; Wilfrid Laurier University; University of Ottawa; National Research Council Canada","funders":"","keywords":"Epitope; Panning (audio); Phage display; Antibody; Molecular biology; Epitope mapping; Biology; Computational biology; Single-domain antibody; Ectodomain; Receptor; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003974186,0.0003509707,0.0002910042,0.0003453342,0.000119557,0.0003077445,0.0002309725,0.0003216392,0.0006067262],"category_scores_gemma":[0.0004747938,0.0001997539,0.0002481816,0.0002084915,0.0001480162,0.0002086233,0.0002283331,0.0005943431,0.0003913717],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002254303,"about_ca_system_score_gemma":0.0002374878,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002830075,"about_ca_topic_score_gemma":0.0007328759,"domain_scores_codex":[0.9998035,0.00003525641,0.0000187058,0.00003617951,0.00007456313,0.00003171965],"domain_scores_gemma":[0.9997339,0.00008284748,0.00005915695,0.00002356937,0.00006966059,0.00003091126],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001850808,0.00001192165,0.0001306216,0.00002437975,0.000003692858,0.00001655521,0.00000814802,0.0000978959,0.9960423,0.00006522268,0.00002242766,0.003558313],"study_design_scores_gemma":[0.0000129339,0.0001507639,0.0008559761,0.000006568437,0.00001434207,0.0002490443,0.0000132829,0.00209795,0.9936522,0.00008208648,0.00286029,0.000004479072],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8163238,0.003074531,0.1759845,0.0002426295,0.00007290896,0.0003925748,0.0004617816,0.0003122955,0.003135013],"genre_scores_gemma":[0.7996059,0.002443015,0.1924873,0.0004247511,0.00003248582,0.0002045701,0.001349656,0.00008424091,0.003368022],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006067262,"threshold_uncertainty_score":0.002101779,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.109595895598213,"score_gpt":0.2769870438968428,"score_spread":0.1673911482986297,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}