{"id":"W2512968948","doi":"10.1111/cbdd.12846","title":"1‐[(Imidazolidin‐2‐yl)imino]‐1<i>H</i>‐indoles as new hypotensive agents: synthesis and<i>in vitro</i>and<i>in vivo</i>biological studies","year":2016,"lang":"en","type":"article","venue":"Chemical Biology & Drug Design","topic":"Chemical Reaction Mechanisms","field":"Chemistry","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"In vivo; In vitro; Pharmacology; Chemistry; Stereochemistry; Combinatorial chemistry; Biochemistry; Medicine; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000920296,0.0003238963,0.0002622968,0.000161646,0.0001178842,0.0001304768,0.0002876532,0.000231542,0.001077728],"category_scores_gemma":[0.00008351578,0.0001184708,0.0002098685,0.0001845493,0.0001082718,0.0001542027,0.0001092271,0.0003430092,0.0003659483],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001803326,"about_ca_system_score_gemma":0.0001634594,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006343488,"about_ca_topic_score_gemma":0.002048634,"domain_scores_codex":[0.9999555,0.000007901684,0.000003253562,0.000007995939,0.000009872348,0.00001547625],"domain_scores_gemma":[0.9999591,0.000004694673,0.00001351145,0.000004037031,0.000008778084,0.000009843916],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002601126,0.0001379677,0.0001614834,0.0003383774,0.00001278978,0.0001964191,0.00004132984,0.000744523,0.9883512,0.0002342245,0.000301879,0.009219507],"study_design_scores_gemma":[0.0001720496,0.005060304,0.005956525,0.00004835704,0.00006536154,0.0006081414,0.00005764989,0.002151596,0.9700874,0.0001254577,0.01562736,0.0000398025],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.94889,0.02550926,0.01249189,0.0002497137,0.0001446167,0.000323156,0.001612721,0.0002871732,0.01049157],"genre_scores_gemma":[0.9757377,0.01099881,0.0071084,0.0001679192,0.00003923249,0.0001424692,0.0009444288,0.00002429479,0.004836797],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001077728,"threshold_uncertainty_score":0.003605425,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0534740116143211,"score_gpt":0.2814116678869703,"score_spread":0.2279376562726492,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}