{"id":"W2513098266","doi":"10.18433/j3g31q","title":"Development of Tat-Conjugated Dendrimer for Transdermal DNA Vaccine Delivery","year":2016,"lang":"en","type":"article","venue":"Journal of Pharmacy & Pharmaceutical Sciences","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Dendrimer; Molecular biology; Transfection; Transdermal; Gene delivery; Oligonucleotide; Flow cytometry; Conjugated system; DNA; Chemistry; Vero cell; DNA vaccination; In vitro; Plasmid; Biochemistry; Biology; Gene; Pharmacology; Organic chemistry","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007843468,0.0001534398,0.0002238804,0.0000982425,0.0001091967,0.00001807514,0.0004734119,0.00004549116,0.0001891549],"category_scores_gemma":[0.00006128404,0.00009381104,0.0001895149,0.0001274517,0.0001832773,0.00003709331,0.0000554062,0.00007500559,0.000006423611],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001780022,"about_ca_system_score_gemma":0.0003660335,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001555325,"about_ca_topic_score_gemma":0.000003825827,"domain_scores_codex":[0.9984353,0.00005827621,0.0006471839,0.0002217507,0.000309614,0.0003279011],"domain_scores_gemma":[0.9990744,0.00006369298,0.0002572368,0.00007474773,0.0003338571,0.0001960513],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007308628,0.0001098404,0.001420874,0.00001854483,0.0001069264,0.000003876215,0.00006334471,0.00001028399,0.9017051,0.00001789747,0.001089571,0.09472291],"study_design_scores_gemma":[0.002209299,0.0003024826,0.0002868216,0.00003910754,0.00005992196,0.00004414149,0.00004777286,0.0001059539,0.8317602,0.00001826902,0.1649983,0.0001276592],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9909088,0.001632602,0.006094856,0.000733424,0.0003557488,0.0001309999,0.00001459913,0.00000358339,0.0001253571],"genre_scores_gemma":[0.9940793,0.0007421089,0.004401392,0.0004207039,0.0002600335,0.000005204649,0.000001919991,0.000009051846,0.0000803013],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1639088,"threshold_uncertainty_score":0.3825503,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06118489551020762,"score_gpt":0.370279690985008,"score_spread":0.3090947954748004,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}