{"id":"W2513098266","doi":"10.18433/j3g31q","title":"Development of Tat-Conjugated Dendrimer for Transdermal DNA Vaccine Delivery","year":2016,"lang":"en","type":"article","venue":"Journal of Pharmacy & Pharmaceutical Sciences","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Dendrimer; Molecular biology; Transfection; Transdermal; Gene delivery; Oligonucleotide; Flow cytometry; Conjugated system; DNA; Chemistry; Vero cell; DNA vaccination; In vitro; Plasmid; Biochemistry; Biology; Gene; Pharmacology; Organic chemistry","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001757699,0.0003382842,0.0002096683,0.0002058857,0.0001312685,0.0002385326,0.0002318756,0.0005575859,0.0005864788],"category_scores_gemma":[0.0002172625,0.0001376712,0.0002827793,0.0001360282,0.0001919524,0.0003150459,0.0002339702,0.0004087437,0.0003718263],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004556265,"about_ca_system_score_gemma":0.0002472121,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003266319,"about_ca_topic_score_gemma":0.0003275659,"domain_scores_codex":[0.9998789,0.00001898137,0.000009620348,0.00003598043,0.00003581241,0.00002073545],"domain_scores_gemma":[0.9999065,0.00001330041,0.00002800986,0.000009860733,0.00002768712,0.0000146772],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002528385,0.00001173392,0.00006963487,0.0000573414,0.000004629911,0.00006153219,0.00001372783,0.0002142396,0.9972091,0.0001446581,0.00004298315,0.002145041],"study_design_scores_gemma":[0.000008726844,0.0001608963,0.000253258,0.000006291413,0.00001003726,0.0002337928,0.000006938814,0.00162692,0.9948238,0.00003302339,0.002831399,0.000004874203],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9328939,0.007562271,0.05419715,0.0005685334,0.0001922014,0.0002495748,0.0002475278,0.0003126223,0.003776242],"genre_scores_gemma":[0.9686438,0.00240907,0.02374004,0.0001486756,0.00001922383,0.0001128227,0.0002721363,0.0000300951,0.00462416],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005864788,"threshold_uncertainty_score":0.003305852,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06118489551020762,"score_gpt":0.370279690985008,"score_spread":0.3090947954748004,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}