{"id":"W2513258422","doi":"10.1016/s0140-6736(16)31324-1","title":"Efficacy and safety of benralizumab for patients with severe asthma uncontrolled with high-dosage inhaled corticosteroids and long-acting β2-agonists (SIROCCO): a randomised, multicentre, placebo-controlled phase 3 trial","year":2016,"lang":"en","type":"article","venue":"The Lancet","topic":"Asthma and respiratory diseases","field":"Medicine","cited_by":1380,"is_retracted":false,"has_abstract":false,"ca_institutions":"Vancouver General Hospital","funders":"AstraZeneca","keywords":"Benralizumab; Medicine; Exacerbation; Placebo; Asthma; Eosinophilia; Mepolizumab; Clinical endpoint; Internal medicine; Eosinophil; Randomized controlled trial; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002214003,0.001750448,0.003418752,0.0003149966,0.00055106,0.00145541,0.0009779502,0.002750531,0.004322623],"category_scores_gemma":[0.002208958,0.0007126126,0.003310809,0.00029932,0.001447547,0.0009510756,0.0005176875,0.003345135,0.0007692116],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001000221,"about_ca_system_score_gemma":0.0009186403,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001691947,"about_ca_topic_score_gemma":0.00283164,"domain_scores_codex":[0.9991664,0.0004276887,0.00005187458,0.0001563384,0.00005941265,0.0001382822],"domain_scores_gemma":[0.9988248,0.0004133125,0.0002700622,0.00008796574,0.00007201952,0.0003318659],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9889576,0.001134406,0.0006659125,0.000709775,0.001043165,0.00003577919,0.00005000677,0.00009437363,0.001618793,0.00005009833,0.0003891845,0.005250941],"study_design_scores_gemma":[0.9749947,0.02140468,0.002360516,0.00003356277,0.0005369586,0.00002457564,0.00001998369,0.0001019244,0.0001453261,0.00004877081,0.0003180481,0.00001086791],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9792252,0.01473776,0.0003415883,0.001227115,0.0008632554,0.001205159,0.0007583845,0.00007789192,0.001563588],"genre_scores_gemma":[0.9914243,0.002926543,0.0006699338,0.001317484,0.000561386,0.0007976613,0.0007386877,0.00001566956,0.001548345],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004322623,"threshold_uncertainty_score":0.01446062,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01064260483431247,"score_gpt":0.2627629240398973,"score_spread":0.2521203192055849,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}