{"id":"W2513426503","doi":"10.1111/head.12905","title":"A Randomized Trial Comparing the Pharmacokinetics, Safety, and Tolerability of DFN‐02, an Intranasal Sumatriptan Spray Containing a Permeation Enhancer, With Intranasal and Subcutaneous Sumatriptan in Healthy Adults","year":2016,"lang":"en","type":"article","venue":"Headache The Journal of Head and Face Pain","topic":"Migraine and Headache Studies","field":"Medicine","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"Celerion (Canada)","funders":"","keywords":"Sumatriptan; Tolerability; Nasal administration; Medicine; Pharmacokinetics; Bioavailability; Crossover study; Bioequivalence; Migraine; Anesthesia; Nasal spray; Pharmacology; Adverse effect; Agonist; Internal medicine; Placebo","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.008021558,0.0002560304,0.001369972,0.000129551,0.0002030692,0.00002346979,0.000104666,0.00008226169,0.00001256256],"category_scores_gemma":[0.0005158915,0.0001133745,0.00009565717,0.0001437073,0.0006882515,0.0001359783,0.00003589198,0.0004747295,8.490876e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007219166,"about_ca_system_score_gemma":0.0001693978,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006162324,"about_ca_topic_score_gemma":0.003763311,"domain_scores_codex":[0.996217,0.001695408,0.001168384,0.0002158084,0.0003719459,0.0003315269],"domain_scores_gemma":[0.9966918,0.0022288,0.0004975684,0.0001891531,0.0001997124,0.0001929641],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9581305,0.000195631,0.01447598,0.0002548531,0.000190792,0.00001988627,0.0158363,0.000008064106,0.001931908,0.00005894082,0.000072981,0.008824185],"study_design_scores_gemma":[0.9444591,0.01932926,0.01073433,0.001837268,0.0007118012,0.001112409,0.01597922,0.004336154,0.0004936324,0.0001995931,0.00048391,0.0003233457],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9776376,0.007836216,0.001606406,0.01145284,0.00003413886,0.00135913,0.00000702416,0.000009752192,0.00005686521],"genre_scores_gemma":[0.9908112,0.008516378,0.0001864744,0.0002551859,0.0001851035,0.000008053178,0.000001687667,0.00001598277,0.00001998395],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01913363,"threshold_uncertainty_score":0.4623278,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02286399515731742,"score_gpt":0.3057354467759983,"score_spread":0.2828714516186809,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}