{"id":"W2513426503","doi":"10.1111/head.12905","title":"A Randomized Trial Comparing the Pharmacokinetics, Safety, and Tolerability of DFN‐02, an Intranasal Sumatriptan Spray Containing a Permeation Enhancer, With Intranasal and Subcutaneous Sumatriptan in Healthy Adults","year":2016,"lang":"en","type":"article","venue":"Headache The Journal of Head and Face Pain","topic":"Migraine and Headache Studies","field":"Medicine","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"Celerion (Canada)","funders":"","keywords":"Sumatriptan; Tolerability; Nasal administration; Medicine; Pharmacokinetics; Bioavailability; Crossover study; Bioequivalence; Migraine; Anesthesia; Nasal spray; Pharmacology; Adverse effect; Agonist; Internal medicine; Placebo","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003232343,0.001504831,0.00297917,0.0003489132,0.0005210681,0.0008588093,0.001009443,0.00220439,0.004468554],"category_scores_gemma":[0.002923941,0.0008933754,0.001793882,0.0004003211,0.002148197,0.001169349,0.0004480392,0.002318373,0.0007766049],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007352658,"about_ca_system_score_gemma":0.00160055,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008879822,"about_ca_topic_score_gemma":0.001096388,"domain_scores_codex":[0.9979665,0.001005884,0.0001679503,0.0004987619,0.0001382031,0.0002225941],"domain_scores_gemma":[0.9969573,0.0009805021,0.0006803447,0.0003486515,0.0002471034,0.0007860799],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9829873,0.01051346,0.0006277588,0.0001191419,0.0002924292,0.00002016254,0.00003195812,0.00007101634,0.002558545,0.00003219458,0.00009286335,0.002653175],"study_design_scores_gemma":[0.7149093,0.2809841,0.002472196,0.000007104806,0.0003499969,0.0000211253,0.0000198238,0.0002589889,0.0006678859,0.00004643642,0.0002493702,0.00001367984],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942847,0.0006487489,0.0005180482,0.0001717719,0.0002853759,0.003293391,0.0003139081,0.00003717794,0.0004468253],"genre_scores_gemma":[0.9891395,0.0004903289,0.002249837,0.0005994437,0.0004305883,0.00499642,0.0004969678,0.00001699523,0.001579991],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004468554,"threshold_uncertainty_score":0.01709449,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02286399515731742,"score_gpt":0.3057354467759983,"score_spread":0.2828714516186809,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}