{"id":"W2513644468","doi":"10.1016/j.addr.2016.08.010","title":"Activatable fluorescence: From small molecule to nanoparticle","year":2016,"lang":"en","type":"review","venue":"Advanced Drug Delivery Reviews","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":99,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; University Health Network; Princess Margaret Cancer Centre","funders":"Canadian Institutes of Health Research; Terry Fox Research Institute; Ontario Institute for Cancer Research; Canada Foundation for Innovation; Natural Sciences and Engineering Research Council of Canada; Princess Margaret Cancer Foundation","keywords":"Biomolecule; Fluorescence; Nanotechnology; Fluorescence-lifetime imaging microscopy; Small molecule; Biological imaging; Molecular imaging; Imaging agent; Drug delivery; Chemistry; Biophysics; Fluorescence in the life sciences; Molecular beacon; Nanoparticle; Förster resonance energy transfer; Materials science; Oligonucleotide; DNA; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005320043,0.001146402,0.001062374,0.001346767,0.0002570015,0.0009730069,0.001163705,0.001378227,0.00271482],"category_scores_gemma":[0.0004417712,0.0004457713,0.0004250675,0.001043964,0.0009755628,0.001861629,0.0009975077,0.002409638,0.002183062],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007881517,"about_ca_system_score_gemma":0.0005657444,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000755271,"about_ca_topic_score_gemma":0.001158033,"domain_scores_codex":[0.9997925,0.00002499564,0.00001389659,0.00005292243,0.00008567366,0.00002988695],"domain_scores_gemma":[0.999854,0.00007882754,0.00002093714,0.000006881708,0.00002637344,0.00001299838],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0000618558,0.00009071175,0.00009022703,0.00918461,0.00004771665,0.000280839,0.00009989528,0.0003843964,0.0332773,0.01017064,0.02472102,0.9215908],"study_design_scores_gemma":[0.00001158336,0.0001019573,0.0002327412,0.0009449741,0.00004133518,0.0009563621,0.00003588695,0.0002193055,0.01387342,0.003291656,0.9802666,0.0000242129],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0003350527,0.9946256,0.001524089,0.0003852582,0.0004071537,0.00000984588,0.00001936983,0.00003407463,0.002659496],"genre_scores_gemma":[0.003204277,0.9899927,0.001256281,0.0005895018,0.0003550495,0.00002458943,0.00004517084,0.00001044211,0.004521972],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.00271482,"threshold_uncertainty_score":0.00908196,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02773707286058839,"score_gpt":0.3160269214091227,"score_spread":0.2882898485485343,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}