{"id":"W2513703067","doi":"10.1017/s0033291716001598","title":"Maternal prenatal depression is associated with decreased placental expression of the imprinted gene <i>PEG3</i>","year":2016,"lang":"en","type":"article","venue":"Psychological Medicine","topic":"Genetic Syndromes and Imprinting","field":"Biochemistry, Genetics and Molecular Biology","cited_by":56,"is_retracted":false,"has_abstract":true,"ca_institutions":"Douglas Mental Health University Institute","funders":"National Institute of Mental Health; Medical Research Council; Directorate for Biological Sciences; NIHR Imperial Biomedical Research Centre; National Institutes of Health; Imperial College London; National Institute for Health and Care Research; Biotechnology and Biological Sciences Research Council; Genesis Research Trust","keywords":"Genomic imprinting; Human placental lactogen; Pregnancy; Edinburgh Postnatal Depression Scale; Antenatal depression; Placenta; Depression (economics); Obstetrics; Cohort; Offspring; Fetus; Placental lactogen; Endocrinology; Medicine; Internal medicine; Biology; Andrology; Gene expression; Gene; Postpartum depression; Genetics; Diabetes mellitus; DNA methylation; Depressive symptoms","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001325842,0.0001554968,0.0001281634,0.0002137304,0.0001647645,0.000281136,0.0001659433,0.0001972332,0.001650234],"category_scores_gemma":[0.0007009212,0.0001344718,0.0001192652,0.0002494876,0.0002150043,0.00005508449,0.0001876009,0.0002501488,0.000119774],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002461188,"about_ca_system_score_gemma":0.0001117581,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004811869,"about_ca_topic_score_gemma":0.004930306,"domain_scores_codex":[0.9998946,0.00001987317,0.000007903689,0.00003396452,0.00002373522,0.00001995525],"domain_scores_gemma":[0.9994447,0.00007178861,0.0003622965,0.00003041884,0.0000340557,0.00005674025],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000966997,0.0000285656,0.9655587,0.00004643367,0.00007847083,0.000747639,0.0001961398,0.00003965828,0.02679673,0.00004346551,0.0002583776,0.005238853],"study_design_scores_gemma":[0.000005120979,0.0000528793,0.9984109,0.000004586356,0.00001602312,0.0006293196,0.00003187052,0.00005529535,0.0006921978,0.00001070694,0.00009014919,0.000001003314],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9993086,0.0001850777,0.000101038,0.00003190785,0.000002485468,0.000002220412,0.0001401282,0.000004720423,0.0002238015],"genre_scores_gemma":[0.9995046,0.0001247447,0.000101001,0.00001850384,0.000002430718,0.000002660989,0.00009634597,0.000001775494,0.0001480884],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004811869,"threshold_uncertainty_score":0.009567738,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01147919011158477,"score_gpt":0.2627150293439754,"score_spread":0.2512358392323906,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}