{"id":"W2513839008","doi":"10.1371/journal.pgen.1006275","title":"Reverse Chemical Genetics: Comprehensive Fitness Profiling Reveals the Spectrum of Drug Target Interactions","year":2016,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"Acute Lymphoblastic Leukemia research","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Cancer Institute; Pharmaceutical Research and Manufacturers of America Foundation; National Aeronautics and Space Administration","keywords":"Biology; Computational biology; Drug resistance; Genetics; Dihydrofolate reductase; Drug; Drug discovery; Pharmacogenetics; Drug development; Bioinformatics; Gene; Pharmacology; Genotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000143406,0.0001932431,0.0003619874,0.00009045104,0.00006671517,0.00001172332,0.0003117929,0.0000847779,0.0003180751],"category_scores_gemma":[0.0003268828,0.0001115343,0.0001186886,0.0002214092,0.0003133983,0.00003311445,0.0002472202,0.0002497809,0.0001294404],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003281806,"about_ca_system_score_gemma":0.0003769001,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004897673,"about_ca_topic_score_gemma":0.000002283821,"domain_scores_codex":[0.9980997,0.0001015765,0.0004516755,0.0003239443,0.0005740558,0.0004489856],"domain_scores_gemma":[0.997901,0.0006472045,0.0001535648,0.0007221655,0.0003842058,0.0001918146],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001818656,0.0001938437,0.008041019,0.0001905472,0.0002171582,0.00002791682,0.0003889135,0.00001914682,0.9838009,0.0001255263,0.006428339,0.0003847749],"study_design_scores_gemma":[0.001615477,0.0001082158,0.0007286723,0.0003041352,0.0001625209,0.00008838165,0.0003100469,0.003701772,0.9888124,0.0007411281,0.003277693,0.0001495756],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9923819,0.00053829,0.0007225155,0.004523255,0.0001819566,0.0007399509,0.00006698157,0.00004133962,0.0008038675],"genre_scores_gemma":[0.9893048,0.0002895556,0.007955396,0.0003510188,0.0004678902,0.0000418929,0.00001540429,0.0000506658,0.001523363],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007312346,"threshold_uncertainty_score":0.4548236,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03131824906181205,"score_gpt":0.2979568282499582,"score_spread":0.2666385791881462,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}