{"id":"W2513903220","doi":"10.3390/cancers8090082","title":"Wnt Drug Discovery: Weaving Through the Screens, Patents and Clinical Trials","year":2016,"lang":"en","type":"review","venue":"Cancers","topic":"Wnt/β-catenin signaling in development and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"","keywords":"Wnt signaling pathway; Drug discovery; Cancer research; Clinical trial; Bioinformatics; Signal transduction; Medicine; Biology; Computational biology; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0019654,0.0004029467,0.001269849,0.00002264355,0.0001438892,0.00009266318,0.0004701466,0.0003655787,0.00004541334],"category_scores_gemma":[0.0004094549,0.0002079581,0.0006348509,0.00008217754,0.000297127,0.000008795944,0.000270189,0.0002504063,0.0000210367],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001938441,"about_ca_system_score_gemma":0.001290947,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006234992,"about_ca_topic_score_gemma":0.00002243997,"domain_scores_codex":[0.9970759,0.0007345138,0.0009830419,0.0006788145,0.0001899388,0.0003378266],"domain_scores_gemma":[0.9984918,0.0002694798,0.0006544109,0.0004495813,0.00005131126,0.00008346549],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00004984206,0.000005995848,0.00006166705,0.0008085869,0.0008086928,0.000003539793,0.00003137068,9.655035e-7,0.00003327518,0.00005675061,0.05919329,0.938946],"study_design_scores_gemma":[0.0003689842,0.00003637185,0.000006585548,0.003205169,0.0004513679,0.000005915931,0.00003000988,2.888462e-7,0.00009786349,0.00005332391,0.9953921,0.0003519593],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001851483,0.9967155,0.0002121325,0.0001007435,0.00141797,0.0006321096,0.0001192698,0.00001187029,0.0006052645],"genre_scores_gemma":[0.0003647956,0.9909424,0.00007450345,0.0002925478,0.001803733,0.0001543245,0.0001545592,0.00006059655,0.006152598],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.938594,"threshold_uncertainty_score":0.8480287,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1376247876862449,"score_gpt":0.4296033468591151,"score_spread":0.2919785591728702,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}